From Metaphor to Mechanism: How LLMs Decode Traditional Chinese Medicine Symbolic Language for Modern Clinical Relevance

Metaphorical expressions are abundant in Traditional Chinese Medicine (TCM), conveying complex disease mechanisms and holistic health concepts through culturally rich and often abstract terminology. Bridging these metaphors to anatomically driven Western medical (WM) concepts poses significant challenges for both automated language processing and real-world clinical practice. To address this gap, we propose a novel multi-agent and chain-of-thought (CoT) framework designed to interpret TCM metaphors accurately and map them to WM pathophysiology. Specifically, our approach combines domain-specialized agents (TCM Expert, WM Expert) with a Coordinator Agent, leveraging stepwise chain-of-thought prompts to ensure transparent reasoning and conflict resolution. We detail a methodology for building a metaphor-rich TCM dataset, discuss strategies for effectively integrating multi-agent collaboration and CoT reasoning, and articulate the theoretical underpinnings that guide metaphor interpretation across distinct medical paradigms. We present a comprehensive system design and highlight both the potential benefits and limitations of our approach, while leaving placeholders for future experimental validation. Our work aims to support clinical decision-making, cross-system educational initiatives, and integrated healthcare research, ultimately offering a robust scaffold for reconciling TCM's symbolic language with the mechanistic focus of Western medicine.

ChipExpert: The Open-Source Integrated-Circuit-Design-Specific Large Language Model

The field of integrated circuit (IC) design is highly specialized, presenting significant barriers to entry and research and development challenges. Although large language models (LLMs) have achieved remarkable success in various domains, existing LLMs often fail to meet the specific needs of students, engineers, and researchers. Consequently, the potential of LLMs in the IC design domain remains largely unexplored. To address these issues, we introduce ChipExpert, the first open-source, instructional LLM specifically tailored for the IC design field. ChipExpert is trained on one of the current best open-source base model (Llama-3 8B). The entire training process encompasses several key stages, including data preparation, continue pre-training, instruction-guided supervised fine-tuning, preference alignment, and evaluation. In the data preparation stage, we construct multiple high-quality custom datasets through manual selection and data synthesis techniques. In the subsequent two stages, ChipExpert acquires a vast amount of IC design knowledge and learns how to respond to user queries professionally. ChipExpert also undergoes an alignment phase, using Direct Preference Optimization, to achieve a high standard of ethical performance. Finally, to mitigate the hallucinations of ChipExpert, we have developed a Retrieval-Augmented Generation (RAG) system, based on the IC design knowledge base. We also released the first IC design benchmark ChipICD-Bench, to evaluate the capabilities of LLMs across multiple IC design sub-domains. Through comprehensive experiments conducted on this benchmark, ChipExpert demonstrated a high level of expertise in IC design knowledge Question-and-Answer tasks.