Patch-based Intuitive Multimodal Prototypes Network (PIMPNet) for Alzheimer's Disease classification

Volumetric neuroimaging examinations like structural Magnetic Resonance Imaging (sMRI) are routinely applied to support the clinical diagnosis of dementia like Alzheimer's Disease (AD). Neuroradiologists examine 3D sMRI to detect and monitor abnormalities in brain morphology due to AD, like global and/or local brain atrophy and shape alteration of characteristic structures. There is a strong research interest in developing diagnostic systems based on Deep Learning (DL) models to analyse sMRI for AD. However, anatomical information extracted from an sMRI examination needs to be interpreted together with patient's age to distinguish AD patterns from the regular alteration due to a normal ageing process. In this context, part-prototype neural networks integrate the computational advantages of DL in an interpretable-by-design architecture and showed promising results in medical imaging applications. We present PIMPNet, the first interpretable multimodal model for 3D images and demographics applied to the binary classification of AD from 3D sMRI and patient's age. Despite age prototypes do not improve predictive performance compared to the single modality model, this lays the foundation for future work in the direction of the model's design and multimodal prototype training process

PIPNet3D: Interpretable Detection of Alzheimer in MRI Scans

Information from neuroimaging examinations (CT, MRI) is increasingly used to support diagnoses of dementia, e.g., Alzheimer's disease. While current clinical practice is mainly based on visual inspection and feature engineering, Deep Learning approaches can be used to automate the analysis and to discover new image-biomarkers. Part-prototype neural networks (PP-NN) are an alternative to standard blackbox models, and have shown promising results in general computer vision. PP-NN's base their reasoning on prototypical image regions that are learned fully unsupervised, and combined with a simple-to-understand decision layer. We present PIPNet3D, a PP-NN for volumetric images. We apply PIPNet3D to the clinical case study of Alzheimer's Disease diagnosis from structural Magnetic Resonance Imaging (sMRI). We assess the quality of prototypes under a systematic evaluation framework, propose new metrics to evaluate brain prototypes and perform an evaluation with domain experts. Our results show that PIPNet3D is an interpretable, compact model for Alzheimer's diagnosis with its reasoning well aligned to medical domain knowledge. Notably, PIPNet3D achieves the same accuracy as its blackbox counterpart; and removing the remaining clinically irrelevant prototypes from its decision process does not decrease predictive performance.

Feature Attribution Explanations for Spiking Neural Networks

Third-generation artificial neural networks, Spiking Neural Networks (SNNs), can be efficiently implemented on hardware. Their implementation on neuromorphic chips opens a broad range of applications, such as machine learning-based autonomous control and intelligent biomedical devices. In critical applications, however, insight into the reasoning of SNNs is important, thus SNNs need to be equipped with the ability to explain how decisions are reached. We present \textit{Temporal Spike Attribution} (TSA), a local explanation method for SNNs. To compute the explanation, we aggregate all information available in model-internal variables: spike times and model weights. We evaluate TSA on artificial and real-world time series data and measure explanation quality w.r.t. multiple quantitative criteria. We find that TSA correctly identifies a small subset of input features relevant to the decision (i.e., is output-complete and compact) and generates similar explanations for similar inputs (i.e., is continuous). Further, our experiments show that incorporating the notion of \emph{absent} spikes improves explanation quality. Our work can serve as a starting point for explainable SNNs, with future implementations on hardware yielding not only predictions but also explanations in a broad range of application scenarios. Source code is available at https://github.com/ElisaNguyen/tsa-explanations.

Worst-Case Morphs using Wasserstein ALI and Improved MIPGAN

A morph is a combination of two separate facial images and contains identity information of two different people. When used in an identity document, both people can be authenticated by a biometric Face Recognition (FR) system. Morphs can be generated using either a landmark-based approach or approaches based on deep learning such as Generative Adversarial Networks (GAN). In a recent paper, we introduced a \emph{worst-case} upper bound on how challenging morphing attacks can be for an FR system. The closer morphs are to this upper bound, the bigger the challenge they pose to FR. We introduced an approach with which it was possible to generate morphs that approximate this upper bound for a known FR system (white box), but not for unknown (black box) FR systems. In this paper, we introduce a morph generation method that can approximate worst-case morphs even when the FR system is not known. A key contribution is that we include the goal of generating difficult morphs \emph{during} training. Our method is based on Adversarially Learned Inference (ALI) and uses concepts from Wasserstein GANs trained with Gradient Penalty, which were introduced to stabilise the training of GANs. We include these concepts to achieve similar improvement in training stability and call the resulting method Wasserstein ALI (WALI). We finetune WALI using loss functions designed specifically to improve the ability to manipulate identity information in facial images and show how it can generate morphs that are more challenging for FR systems than landmark- or GAN-based morphs. We also show how our findings can be used to improve MIPGAN, an existing StyleGAN-based morph generator.

The Co-12 Recipe for Evaluating Interpretable Part-Prototype Image Classifiers

Interpretable part-prototype models are computer vision models that are explainable by design. The models learn prototypical parts and recognise these components in an image, thereby combining classification and explanation. Despite the recent attention for intrinsically interpretable models, there is no comprehensive overview on evaluating the explanation quality of interpretable part-prototype models. Based on the Co-12 properties for explanation quality as introduced in arXiv:2201.08164 (e.g., correctness, completeness, compactness), we review existing work that evaluates part-prototype models, reveal research gaps and outline future approaches for evaluation of the explanation quality of part-prototype models. This paper, therefore, contributes to the progression and maturity of this relatively new research field on interpretable part-prototype models. We additionally provide a ``Co-12 cheat sheet'' that acts as a concise summary of our findings on evaluating part-prototype models.

Interpreting and Correcting Medical Image Classification with PIP-Net

Part-prototype models are explainable-by-design image classifiers, and a promising alternative to black box AI. This paper explores the applicability and potential of interpretable machine learning, in particular PIP-Net, for automated diagnosis support on real-world medical imaging data. PIP-Net learns human-understandable prototypical image parts and we evaluate its accuracy and interpretability for fracture detection and skin cancer diagnosis. We find that PIP-Net's decision making process is in line with medical classification standards, while only provided with image-level class labels. Because of PIP-Net's unsupervised pretraining of prototypes, data quality problems such as undesired text in an X-ray or labelling errors can be easily identified. Additionally, we are the first to show that humans can manually correct the reasoning of PIP-Net by directly disabling undesired prototypes. We conclude that part-prototype models are promising for medical applications due to their interpretability and potential for advanced model debugging.

From Anecdotal Evidence to Quantitative Evaluation Methods: A Systematic Review on Evaluating Explainable AI

The rising popularity of explainable artificial intelligence (XAI) to understand high-performing black boxes, also raised the question of how to evaluate explanations of machine learning (ML) models. While interpretability and explainability are often presented as a subjectively validated binary property, we consider it a multi-faceted concept. We identify 12 conceptual properties, such as Compactness and Correctness, that should be evaluated for comprehensively assessing the quality of an explanation. Our so-called Co-12 properties serve as categorization scheme for systematically reviewing the evaluation practice of more than 300 papers published in the last 7 years at major AI and ML conferences that introduce an XAI method. We find that 1 in 3 papers evaluate exclusively with anecdotal evidence, and 1 in 5 papers evaluate with users. We also contribute to the call for objective, quantifiable evaluation methods by presenting an extensive overview of quantitative XAI evaluation methods. This systematic collection of evaluation methods provides researchers and practitioners with concrete tools to thoroughly validate, benchmark and compare new and existing XAI methods. This also opens up opportunities to include quantitative metrics as optimization criteria during model training in order to optimize for accuracy and interpretability simultaneously.

Neural Prototype Trees for Interpretable Fine-grained Image Recognition

Interpretable machine learning addresses the black-box nature of deep neural networks. Visual prototypes have been suggested for intrinsically interpretable image recognition, instead of generating post-hoc explanations that approximate a trained model. However, a large number of prototypes can be overwhelming. To reduce explanation size and improve interpretability, we propose the Neural Prototype Tree (ProtoTree), a deep learning method that includes prototypes in an interpretable decision tree to faithfully visualize the entire model. In addition to global interpretability, a path in the tree explains a single prediction. Each node in our binary tree contains a trainable prototypical part. The presence or absence of this prototype in an image determines the routing through a node. Decision making is therefore similar to human reasoning: Does the bird have a red throat? And an elongated beak? Then it's a hummingbird! We tune the accuracy-interpretability trade-off using ensembling and pruning. We apply pruning without sacrificing accuracy, resulting in a small tree with only 8 prototypes along a path to classify a bird from 200 species. An ensemble of 5 ProtoTrees achieves competitive accuracy on the CUB-200-2011 and Stanford Cars data sets. Code is available at https://github.com/M-Nauta/ProtoTree

This Looks Like That, Because ... Explaining Prototypes for Interpretable Image Recognition

Image recognition with prototypes is considered an interpretable alternative for black box deep learning models. Classification depends on the extent to which a test image "looks like" a prototype. However, perceptual similarity for humans can be different from the similarity learnt by the model. A user is unaware of the underlying classification strategy and does not know which image characteristics (e.g., color or shape) is the dominant characteristic for the decision. We address this ambiguity and argue that prototypes should be explained. Only visualizing prototypes can be insufficient for understanding what a prototype exactly represents, and why a prototype and an image are considered similar. We improve interpretability by automatically enhancing prototypes with extra information about visual characteristics considered important by the model. Specifically, our method quantifies the influence of color hue, shape, texture, contrast and saturation in a prototype. We apply our method to the existing Prototypical Part Network (ProtoPNet) and show that our explanations clarify the meaning of a prototype which might have been interpreted incorrectly otherwise. We also reveal that visually similar prototypes can have the same explanations, indicating redundancy. Because of the generality of our approach, it can improve the interpretability of any similarity-based method for prototypical image recognition.