Abstract:The rise of large-scale socio-technical systems in which humans interact with artificial intelligence (AI) systems (including assistants and recommenders, in short AIs) multiplies the opportunity for the emergence of collective phenomena and tipping points, with unexpected, possibly unintended, consequences. For example, navigation systems' suggestions may create chaos if too many drivers are directed on the same route, and personalised recommendations on social media may amplify polarisation, filter bubbles, and radicalisation. On the other hand, we may learn how to foster the "wisdom of crowds" and collective action effects to face social and environmental challenges. In order to understand the impact of AI on socio-technical systems and design next-generation AIs that team with humans to help overcome societal problems rather than exacerbate them, we propose to build the foundations of Social AI at the intersection of Complex Systems, Network Science and AI. In this perspective paper, we discuss the main open questions in Social AI, outlining possible technical and scientific challenges and suggesting research avenues.