Look a Group at Once: Multi-Slide Modeling for Survival Prediction

Survival prediction is a critical task in pathology. In clinical practice, pathologists often examine multiple cases, leveraging a broader spectrum of cancer phenotypes to enhance pathological assessment. Despite significant advancements in deep learning, current solutions typically model each slide as a sample, struggling to effectively capture comparable and slide-agnostic pathological features. In this paper, we introduce GroupMIL, a novel framework inspired by the clinical practice of collective analysis, which models multiple slides as a single sample and organizes groups of patches and slides sequentially to capture cross-slide prognostic features. We also present GPAMamba, a model designed to facilitate intra- and inter-slide feature interactions, effectively capturing local micro-environmental characteristics within slide-level graphs while uncovering essential prognostic patterns across an extended patch sequence within the group framework. Furthermore, we develop a dual-head predictor that delivers comprehensive survival risk and probability assessments for each patient. Extensive empirical evaluations demonstrate that our model significantly outperforms state-of-the-art approaches across five datasets from The Cancer Genome Atlas.

Symmetric low-rank representation for subspace clustering

We propose a symmetric low-rank representation (SLRR) method for subspace clustering, which assumes that a data set is approximately drawn from the union of multiple subspaces. The proposed technique can reveal the membership of multiple subspaces through the self-expressiveness property of the data. In particular, the SLRR method considers a collaborative representation combined with low-rank matrix recovery techniques as a low-rank representation to learn a symmetric low-rank representation, which preserves the subspace structures of high-dimensional data. In contrast to performing iterative singular value decomposition in some existing low-rank representation based algorithms, the symmetric low-rank representation in the SLRR method can be calculated as a closed form solution by solving the symmetric low-rank optimization problem. By making use of the angular information of the principal directions of the symmetric low-rank representation, an affinity graph matrix is constructed for spectral clustering. Extensive experimental results show that it outperforms state-of-the-art subspace clustering algorithms.