Automatic facial axes standardization of 3D fetal ultrasound images

Craniofacial anomalies indicate early developmental disturbances and are usually linked to many genetic syndromes. Early diagnosis is critical, yet ultrasound (US) examinations often fail to identify these features. This study presents an AI-driven tool to assist clinicians in standardizing fetal facial axes/planes in 3D US, reducing sonographer workload and facilitating the facial evaluation. Our network, structured into three blocks-feature extractor, rotation and translation regression, and spatial transformer-processes three orthogonal 2D slices to estimate the necessary transformations for standardizing the facial planes in the 3D US. These transformations are applied to the original 3D US using a differentiable module (the spatial transformer block), yielding a standardized 3D US and the corresponding 2D facial standard planes. The dataset used consists of 1180 fetal facial 3D US images acquired between weeks 20 and 35 of gestation. Results show that our network considerably reduces inter-observer rotation variability in the test set, with a mean geodesic angle difference of 14.12$^{\circ}$ $\pm$ 18.27$^{\circ}$ and an Euclidean angle error of 7.45$^{\circ}$ $\pm$ 14.88$^{\circ}$. These findings demonstrate the network's ability to effectively standardize facial axes, crucial for consistent fetal facial assessments. In conclusion, the proposed network demonstrates potential for improving the consistency and accuracy of fetal facial assessments in clinical settings, facilitating early evaluation of craniofacial anomalies.

PhysFlow: Skin tone transfer for remote heart rate estimation through conditional normalizing flows

In recent years, deep learning methods have shown impressive results for camera-based remote physiological signal estimation, clearly surpassing traditional methods. However, the performance and generalization ability of Deep Neural Networks heavily depends on rich training data truly representing different factors of variation encountered in real applications. Unfortunately, many current remote photoplethysmography (rPPG) datasets lack diversity, particularly in darker skin tones, leading to biased performance of existing rPPG approaches. To mitigate this bias, we introduce PhysFlow, a novel method for augmenting skin diversity in remote heart rate estimation using conditional normalizing flows. PhysFlow adopts end-to-end training optimization, enabling simultaneous training of supervised rPPG approaches on both original and generated data. Additionally, we condition our model using CIELAB color space skin features directly extracted from the facial videos without the need for skin-tone labels. We validate PhysFlow on publicly available datasets, UCLA-rPPG and MMPD, demonstrating reduced heart rate error, particularly in dark skin tones. Furthermore, we demonstrate its versatility and adaptability across different data-driven rPPG methods.

Data Alchemy: Mitigating Cross-Site Model Variability Through Test Time Data Calibration

Deploying deep learning-based imaging tools across various clinical sites poses significant challenges due to inherent domain shifts and regulatory hurdles associated with site-specific fine-tuning. For histopathology, stain normalization techniques can mitigate discrepancies, but they often fall short of eliminating inter-site variations. Therefore, we present Data Alchemy, an explainable stain normalization method combined with test time data calibration via a template learning framework to overcome barriers in cross-site analysis. Data Alchemy handles shifts inherent to multi-site data and minimizes them without needing to change the weights of the normalization or classifier networks. Our approach extends to unseen sites in various clinical settings where data domain discrepancies are unknown. Extensive experiments highlight the efficacy of our framework in tumor classification in hematoxylin and eosin-stained patches. Our explainable normalization method boosts classification tasks' area under the precision-recall curve(AUPR) by 0.165, 0.545 to 0.710. Additionally, Data Alchemy further reduces the multisite classification domain gap, by improving the 0.710 AUPR an additional 0.142, elevating classification performance further to 0.852, from 0.545. Our Data Alchemy framework can popularize precision medicine with minimal operational overhead by allowing for the seamless integration of pre-trained deep learning-based clinical tools across multiple sites.