Reconfigurable intelligent surfaces (RISs) are key enablers for integrated sensing and communication (ISAC) systems in the 6G communication era. With the capability of dynamically shaping the channel, RISs can enhance communication coverage. Additionally, RISs can serve as additional anchors with high angular resolution to improve localization and sensing services in extreme scenarios. However, knowledge of anchors' states such as position, orientation, and hardware impairments are crucial for localization and sensing applications, requiring dedicated calibration, including geometry and hardware calibration. This paper provides an overview of various types of RIS calibration, their impacts, and the challenges they pose in ISAC systems.