Automating the Diagnosis of Human Vision Disorders by Cross-modal 3D Generation

Understanding the hidden mechanisms behind human's visual perception is a fundamental quest in neuroscience, underpins a wide variety of critical applications, e.g. clinical diagnosis. To that end, investigating into the neural responses of human mind activities, such as functional Magnetic Resonance Imaging (fMRI), has been a significant research vehicle. However, analyzing fMRI signals is challenging, costly, daunting, and demanding for professional training. Despite remarkable progress in artificial intelligence (AI) based fMRI analysis, existing solutions are limited and far away from being clinically meaningful. In this context, we leap forward to demonstrate how AI can go beyond the current state of the art by decoding fMRI into visually plausible 3D visuals, enabling automatic clinical analysis of fMRI data, even without healthcare professionals. Innovationally, we reformulate the task of analyzing fMRI data as a conditional 3D scene reconstruction problem. We design a novel cross-modal 3D scene representation learning method, Brain3D, that takes as input the fMRI data of a subject who was presented with a 2D object image, and yields as output the corresponding 3D object visuals. Importantly, we show that in simulated scenarios our AI agent captures the distinct functionalities of each region of human vision system as well as their intricate interplay relationships, aligning remarkably with the established discoveries of neuroscience. Non-expert diagnosis indicate that Brain3D can successfully identify the disordered brain regions, such as V1, V2, V3, V4, and the medial temporal lobe (MTL) within the human visual system. We also present results in cross-modal 3D visual construction setting, showcasing the perception quality of our 3D scene generation.

CEIR: Concept-based Explainable Image Representation Learning

In modern machine learning, the trend of harnessing self-supervised learning to derive high-quality representations without label dependency has garnered significant attention. However, the absence of label information, coupled with the inherently high-dimensional nature, improves the difficulty for the interpretation of learned representations. Consequently, indirect evaluations become the popular metric for evaluating the quality of these features, leading to a biased validation of the learned representation rationale. To address these challenges, we introduce a novel approach termed Concept-based Explainable Image Representation (CEIR). Initially, using the Concept-based Model (CBM) incorporated with pretrained CLIP and concepts generated by GPT-4, we project input images into a concept vector space. Subsequently, a Variational Autoencoder (VAE) learns the latent representation from these projected concepts, which serves as the final image representation. Due to the capability of the representation to encapsulate high-level, semantically relevant concepts, the model allows for attributions to a human-comprehensible concept space. This not only enhances interpretability but also preserves the robustness essential for downstream tasks. For instance, our method exhibits state-of-the-art unsupervised clustering performance on benchmarks such as CIFAR10, CIFAR100, and STL10. Furthermore, capitalizing on the universality of human conceptual understanding, CEIR can seamlessly extract the related concept from open-world images without fine-tuning. This offers a fresh approach to automatic label generation and label manipulation.