Are Traditional Deep Learning Model Approaches as Effective as a Retinal-Specific Foundation Model for Ocular and Systemic Disease Detection?

Background: RETFound, a self-supervised, retina-specific foundation model (FM), showed potential in downstream applications. However, its comparative performance with traditional deep learning (DL) models remains incompletely understood. This study aimed to evaluate RETFound against three ImageNet-pretrained supervised DL models (ResNet50, ViT-base, SwinV2) in detecting ocular and systemic diseases. Methods: We fine-tuned/trained RETFound and three DL models on full datasets, 50%, 20%, and fixed sample sizes (400, 200, 100 images, with half comprising disease cases; for each DR severity class, 100 and 50 cases were used. Fine-tuned models were tested internally using the SEED (53,090 images) and APTOS-2019 (3,672 images) datasets and externally validated on population-based (BES, CIEMS, SP2, UKBB) and open-source datasets (ODIR-5k, PAPILA, GAMMA, IDRiD, MESSIDOR-2). Model performance was compared using area under the receiver operating characteristic curve (AUC) and Z-tests with Bonferroni correction (P<0.05/3). Interpretation: Traditional DL models are mostly comparable to RETFound for ocular disease detection with large datasets. However, RETFound is superior in systemic disease detection with smaller datasets. These findings offer valuable insights into the respective merits and limitation of traditional models and FMs.

Generative-Adversarial-Networks-based Ghost Recognition

Nowadays, target recognition technique plays an important role in many fields. However, the existing image information based methods suffer from the influence of target image quality. In addition, some methods also need image reconstruction, which will bring additional time cost. In this paper, we propose a novel coincidence recognition method combining ghost imaging (GI) and generative adversarial networks (GAN). Based on the mechanism of GI, a set of random speckles sequence is employed to illuminate target, and a bucket detector without resolution is utilized to receive echo signal. The bucket signal sequence formed after continuous detections is constructed into a bucket signal array, which is regarded as the sample of GAN. Then, conditional GAN is used to map bucket signal array and target category. In practical application, the speckles sequence in training step is still employed to illuminate target, and the bucket signal array is input GAN for recognition. The proposed method can improve the problems caused by existing recognition methods that based on image information, and provide a certain turbulence-free ability. Extensive experiments are show that the proposed method achieves promising performance.