Multi-Task Adversarial Variational Autoencoder for Estimating Biological Brain Age with Multimodal Neuroimaging

Despite advances in deep learning for estimating brain age from structural MRI data, incorporating functional MRI data is challenging due to its complex structure and the noisy nature of functional connectivity measurements. To address this, we present the Multitask Adversarial Variational Autoencoder, a custom deep learning framework designed to improve brain age predictions through multimodal MRI data integration. This model separates latent variables into generic and unique codes, isolating shared and modality-specific features. By integrating multitask learning with sex classification as an additional task, the model captures sex-specific aging patterns. Evaluated on the OpenBHB dataset, a large multisite brain MRI collection, the model achieves a mean absolute error of 2.77 years, outperforming traditional methods. This success positions M-AVAE as a powerful tool for metaverse-based healthcare applications in brain age estimation.

Stacked U-Nets with Self-Assisted Priors Towards Robust Correction of Rigid Motion Artifact in Brain MRI

In this paper, we develop an efficient retrospective deep learning method called stacked U-Nets with self-assisted priors to address the problem of rigid motion artifacts in MRI. The proposed work exploits the usage of additional knowledge priors from the corrupted images themselves without the need for additional contrast data. The proposed network learns missed structural details through sharing auxiliary information from the contiguous slices of the same distorted subject. We further design a refinement stacked U-Nets that facilitates preserving of the image spatial details and hence improves the pixel-to-pixel dependency. To perform network training, simulation of MRI motion artifacts is inevitable. We present an intensive analysis using various types of image priors: the proposed self-assisted priors and priors from other image contrast of the same subject. The experimental analysis proves the effectiveness and feasibility of our self-assisted priors since it does not require any further data scans.