D$^2$-DPM: Dual Denoising for Quantized Diffusion Probabilistic Models

Diffusion models have achieved cutting-edge performance in image generation. However, their lengthy denoising process and computationally intensive score estimation network impede their scalability in low-latency and resource-constrained scenarios. Post-training quantization (PTQ) compresses and accelerates diffusion models without retraining, but it inevitably introduces additional quantization noise, resulting in mean and variance deviations. In this work, we propose D2-DPM, a dual denoising mechanism aimed at precisely mitigating the adverse effects of quantization noise on the noise estimation network. Specifically, we first unravel the impact of quantization noise on the sampling equation into two components: the mean deviation and the variance deviation. The mean deviation alters the drift coefficient of the sampling equation, influencing the trajectory trend, while the variance deviation magnifies the diffusion coefficient, impacting the convergence of the sampling trajectory. The proposed D2-DPM is thus devised to denoise the quantization noise at each time step, and then denoise the noisy sample through the inverse diffusion iterations. Experimental results demonstrate that D2-DPM achieves superior generation quality, yielding a 1.42 lower FID than the full-precision model while achieving 3.99x compression and 11.67x bit-operation acceleration.

Graph-Guided Test-Time Adaptation for Glaucoma Diagnosis using Fundus Photography

Glaucoma is a leading cause of irreversible blindness worldwide. While deep learning approaches using fundus images have largely improved early diagnosis of glaucoma, variations in images from different devices and locations (known as domain shifts) challenge the use of pre-trained models in real-world settings. To address this, we propose a novel Graph-guided Test-Time Adaptation (GTTA) framework to generalize glaucoma diagnosis models to unseen test environments. GTTA integrates the topological information of fundus images into the model training, enhancing the model's transferability and reducing the risk of learning spurious correlation. During inference, GTTA introduces a novel test-time training objective to make the source-trained classifier progressively adapt to target patterns with reliable class conditional estimation and consistency regularization. Experiments on cross-domain glaucoma diagnosis benchmarks demonstrate the superiority of the overall framework and individual components under different backbone networks.