EEG-estimated functional connectivity, and not behavior, differentiates Parkinson's patients from health controls during the Simon conflict task

Neural biomarkers that can classify or predict disease are of broad interest to the neurological and psychiatric communities. Such biomarkers can be informative of disease state or treatment efficacy, even before there are changes in symptoms and/or behavior. This work investigates EEG-estimated functional connectivity (FC) as a Parkinson's Disease (PD) biomarker. Specifically, we investigate FC mediated via neural oscillations and consider such activity during the Simons conflict task. This task yields sensory-motor conflict, and one might expect differences in behavior between PD patients and healthy controls (HCs). In addition to considering spatially focused approaches, such as FC, as a biomarker, we also consider temporal biomarkers, which are more sensitive to ongoing changes in neural activity. We find that FC, estimated from delta (1-4Hz) and theta (4-7Hz) oscillations, yields spatial FC patterns significantly better at distinguishing PD from HC than temporal features or behavior. This study reinforces that FC in spectral bands is informative of differences in brain-wide processes and can serve as a biomarker distinguishing normal brain function from that seen in disease.

Enabling Multi-Robot Collaboration from Single-Human Guidance

Learning collaborative behaviors is essential for multi-agent systems. Traditionally, multi-agent reinforcement learning solves this implicitly through a joint reward and centralized observations, assuming collaborative behavior will emerge. Other studies propose to learn from demonstrations of a group of collaborative experts. Instead, we propose an efficient and explicit way of learning collaborative behaviors in multi-agent systems by leveraging expertise from only a single human. Our insight is that humans can naturally take on various roles in a team. We show that agents can effectively learn to collaborate by allowing a human operator to dynamically switch between controlling agents for a short period and incorporating a human-like theory-of-mind model of teammates. Our experiments showed that our method improves the success rate of a challenging collaborative hide-and-seek task by up to 58$% with only 40 minutes of human guidance. We further demonstrate our findings transfer to the real world by conducting multi-robot experiments.

Circular Clustering with Polar Coordinate Reconstruction

There is a growing interest in characterizing circular data found in biological systems. Such data are wide ranging and varied, from signal phase in neural recordings to nucleotide sequences in round genomes. Traditional clustering algorithms are often inadequate due to their limited ability to distinguish differences in the periodic component. Current clustering schemes that work in a polar coordinate system have limitations, such as being only angle-focused or lacking generality. To overcome these limitations, we propose a new analysis framework that utilizes projections onto a cylindrical coordinate system to better represent objects in a polar coordinate system. Using the mathematical properties of circular data, we show our approach always finds the correct clustering result within the reconstructed dataset, given sufficient periodic repetitions of the data. Our approach is generally applicable and adaptable and can be incorporated into most state-of-the-art clustering algorithms. We demonstrate on synthetic and real data that our method generates more appropriate and consistent clustering results compared to standard methods. In summary, our proposed analysis framework overcomes the limitations of existing polar coordinate-based clustering methods and provides a more accurate and efficient way to cluster circular data.

Fixating on Attention: Integrating Human Eye Tracking into Vision Transformers

Modern transformer-based models designed for computer vision have outperformed humans across a spectrum of visual tasks. However, critical tasks, such as medical image interpretation or autonomous driving, still require reliance on human judgments. This work demonstrates how human visual input, specifically fixations collected from an eye-tracking device, can be integrated into transformer models to improve accuracy across multiple driving situations and datasets. First, we establish the significance of fixation regions in left-right driving decisions, as observed in both human subjects and a Vision Transformer (ViT). By comparing the similarity between human fixation maps and ViT attention weights, we reveal the dynamics of overlap across individual heads and layers. This overlap is exploited for model pruning without compromising accuracy. Thereafter, we incorporate information from the driving scene with fixation data, employing a "joint space-fixation" (JSF) attention setup. Lastly, we propose a "fixation-attention intersection" (FAX) loss to train the ViT model to attend to the same regions that humans fixated on. We find that the ViT performance is improved in accuracy and number of training epochs when using JSF and FAX. These results hold significant implications for human-guided artificial intelligence.

Bayesian Beta-Bernoulli Process Sparse Coding with Deep Neural Networks

Several approximate inference methods have been proposed for deep discrete latent variable models. However, non-parametric methods which have previously been successfully employed for classical sparse coding models have largely been unexplored in the context of deep models. We propose a non-parametric iterative algorithm for learning discrete latent representations in such deep models. Additionally, to learn scale invariant discrete features, we propose local data scaling variables. Lastly, to encourage sparsity in our representations, we propose a Beta-Bernoulli process prior on the latent factors. We evaluate our spare coding model coupled with different likelihood models. We evaluate our method across datasets with varying characteristics and compare our results to current amortized approximate inference methods.

Inferring latent neural sources via deep transcoding of simultaneously acquired EEG and fMRI

Simultaneous EEG-fMRI is a multi-modal neuroimaging technique that provides complementary spatial and temporal resolution. Challenging has been developing principled and interpretable approaches for fusing the modalities, specifically approaches enabling inference of latent source spaces representative of neural activity. In this paper, we address this inference problem within the framework of transcoding -- mapping from a specific encoding (modality) to a decoding (the latent source space) and then encoding the latent source space to the other modality. Specifically, we develop a symmetric method consisting of a cyclic convolutional transcoder that transcodes EEG to fMRI and vice versa. Without any prior knowledge of either the hemodynamic response function or lead field matrix, the complete data-driven method exploits the temporal and spatial relationships between the modalities and latent source spaces to learn these mappings. We quantify, for both the simulated and real EEG-fMRI data, how well the modalities can be transcoded from one to another as well as the source spaces that are recovered, all evaluated on unseen data. In addition to enabling a new way to symmetrically infer a latent source space, the method can also be seen as low-cost computational neuroimaging -- i.e. generating an 'expensive' fMRI BOLD image from 'low cost' EEG data.

Improving Prediction of Cognitive Performance using Deep Neural Networks in Sparse Data

Cognition in midlife is an important predictor of age-related mental decline and statistical models that predict cognitive performance can be useful for predicting decline. However, existing models struggle to capture complex relationships between physical, sociodemographic, psychological and mental health factors that effect cognition. Using data from an observational, cohort study, Midlife in the United States (MIDUS), we modeled a large number of variables to predict executive function and episodic memory measures. We used cross-sectional and longitudinal outcomes with varying sparsity, or amount of missing data. Deep neural network (DNN) models consistently ranked highest in all of the cognitive performance prediction tasks, as assessed with root mean squared error (RMSE) on out-of-sample data. RMSE differences between DNN and other model types were statistically significant (T(8) = -3.70; p < 0.05). The interaction effect between model type and sparsity was significant (F(9)=59.20; p < 0.01), indicating the success of DNNs can partly be attributed to their robustness and ability to model hierarchical relationships between health-related factors. Our findings underscore the potential of neural networks to model clinical datasets and allow better understanding of factors that lead to cognitive decline.

Bayesian recurrent state space model for rs-fMRI

We propose a hierarchical Bayesian recurrent state space model for modeling switching network connectivity in resting state fMRI data. Our model allows us to uncover shared network patterns across disease conditions. We evaluate our method on the ADNI2 dataset by inferring latent state patterns corresponding to altered neural circuits in individuals with Mild Cognitive Impairment (MCI). In addition to states shared across healthy and individuals with MCI, we discover latent states that are predominantly observed in individuals with MCI. Our model outperforms current state of the art deep learning method on ADNI2 dataset.

Deep Bayesian Nonparametric Factor Analysis

We propose a deep generative factor analysis model with beta process prior that can approximate complex non-factorial distributions over the latent codes. We outline a stochastic EM algorithm for scalable inference in a specific instantiation of this model and present some preliminary results.

Latent neural source recovery via transcoding of simultaneous EEG-fMRI

Simultaneous EEG-fMRI is a multi-modal neuroimaging technique that provides complementary spatial and temporal resolution for inferring a latent source space of neural activity. In this paper we address this inference problem within the framework of transcoding -- mapping from a specific encoding (modality) to a decoding (the latent source space) and then encoding the latent source space to the other modality. Specifically, we develop a symmetric method consisting of a cyclic convolutional transcoder that transcodes EEG to fMRI and vice versa. Without any prior knowledge of either the hemodynamic response function or lead field matrix, the method exploits the temporal and spatial relationships between the modalities and latent source spaces to learn these mappings. We show, for real EEG-fMRI data, how well the modalities can be transcoded from one to another as well as the source spaces that are recovered, all on unseen data. In addition to enabling a new way to symmetrically infer a latent source space, the method can also be seen as low-cost computational neuroimaging -- i.e. generating an 'expensive' fMRI BOLD image from 'low cost' EEG data.