Advances in Automated Fetal Brain MRI Segmentation and Biometry: Insights from the FeTA 2024 Challenge

Accurate fetal brain tissue segmentation and biometric analysis are essential for studying brain development in utero. The FeTA Challenge 2024 advanced automated fetal brain MRI analysis by introducing biometry prediction as a new task alongside tissue segmentation. For the first time, our diverse multi-centric test set included data from a new low-field (0.55T) MRI dataset. Evaluation metrics were also expanded to include the topology-specific Euler characteristic difference (ED). Sixteen teams submitted segmentation methods, most of which performed consistently across both high- and low-field scans. However, longitudinal trends indicate that segmentation accuracy may be reaching a plateau, with results now approaching inter-rater variability. The ED metric uncovered topological differences that were missed by conventional metrics, while the low-field dataset achieved the highest segmentation scores, highlighting the potential of affordable imaging systems when paired with high-quality reconstruction. Seven teams participated in the biometry task, but most methods failed to outperform a simple baseline that predicted measurements based solely on gestational age, underscoring the challenge of extracting reliable biometric estimates from image data alone. Domain shift analysis identified image quality as the most significant factor affecting model generalization, with super-resolution pipelines also playing a substantial role. Other factors, such as gestational age, pathology, and acquisition site, had smaller, though still measurable, effects. Overall, FeTA 2024 offers a comprehensive benchmark for multi-class segmentation and biometry estimation in fetal brain MRI, underscoring the need for data-centric approaches, improved topological evaluation, and greater dataset diversity to enable clinically robust and generalizable AI tools.

How to Blend Concepts in Diffusion Models

For the last decade, there has been a push to use multi-dimensional (latent) spaces to represent concepts; and yet how to manipulate these concepts or reason with them remains largely unclear. Some recent methods exploit multiple latent representations and their connection, making this research question even more entangled. Our goal is to understand how operations in the latent space affect the underlying concepts. To that end, we explore the task of concept blending through diffusion models. Diffusion models are based on a connection between a latent representation of textual prompts and a latent space that enables image reconstruction and generation. This task allows us to try different text-based combination strategies, and evaluate easily through a visual analysis. Our conclusion is that concept blending through space manipulation is possible, although the best strategy depends on the context of the blend.