Style Transfer Enabled Sim2Real Framework for Efficient Learning of Robotic Ultrasound Image Analysis Using Simulated Data

Robotic ultrasound (US) systems have shown great potential to make US examinations easier and more accurate. Recently, various machine learning techniques have been proposed to realize automatic US image interpretation for robotic US acquisition tasks. However, obtaining large amounts of real US imaging data for training is usually expensive or even unfeasible in some clinical applications. An alternative is to build a simulator to generate synthetic US data for training, but the differences between simulated and real US images may result in poor model performance. This work presents a Sim2Real framework to efficiently learn robotic US image analysis tasks based only on simulated data for real-world deployment. A style transfer module is proposed based on unsupervised contrastive learning and used as a preprocessing step to convert the real US images into the simulation style. Thereafter, a task-relevant model is designed to combine CNNs with vision transformers to generate the task-dependent prediction with improved generalization ability. We demonstrate the effectiveness of our method in an image regression task to predict the probe position based on US images in robotic transesophageal echocardiography (TEE). Our results show that using only simulated US data and a small amount of unlabelled real data for training, our method can achieve comparable performance to semi-supervised and fully supervised learning methods. Moreover, the effectiveness of our previously proposed CT-based US image simulation method is also indirectly confirmed.

Deep Learning-based Biological Anatomical Landmark Detection in Colonoscopy Videos

Colonoscopy is a standard imaging tool for visualizing the entire gastrointestinal (GI) tract of patients to capture lesion areas. However, it takes the clinicians excessive time to review a large number of images extracted from colonoscopy videos. Thus, automatic detection of biological anatomical landmarks within the colon is highly demanded, which can help reduce the burden of clinicians by providing guidance information for the locations of lesion areas. In this article, we propose a novel deep learning-based approach to detect biological anatomical landmarks in colonoscopy videos. First, raw colonoscopy video sequences are pre-processed to reject interference frames. Second, a ResNet-101 based network is used to detect three biological anatomical landmarks separately to obtain the intermediate detection results. Third, to achieve more reliable localization of the landmark periods within the whole video period, we propose to post-process the intermediate detection results by identifying the incorrectly predicted frames based on their temporal distribution and reassigning them back to the correct class. Finally, the average detection accuracy reaches 99.75\%. Meanwhile, the average IoU of 0.91 shows a high degree of similarity between our predicted landmark periods and ground truth. The experimental results demonstrate that our proposed model is capable of accurately detecting and localizing biological anatomical landmarks from colonoscopy videos.