ImprovDML: Improved Trade-off in Private Byzantine-Resilient Distributed Machine Learning

Jointly addressing Byzantine attacks and privacy leakage in distributed machine learning (DML) has become an important issue. A common strategy involves integrating Byzantine-resilient aggregation rules with differential privacy mechanisms. However, the incorporation of these techniques often results in a significant degradation in model accuracy. To address this issue, we propose a decentralized DML framework, named ImprovDML, that achieves high model accuracy while simultaneously ensuring privacy preservation and resilience to Byzantine attacks. The framework leverages a kind of resilient vector consensus algorithms that can compute a point within the normal (non-Byzantine) agents' convex hull for resilient aggregation at each iteration. Then, multivariate Gaussian noises are introduced to the gradients for privacy preservation. We provide convergence guarantees and derive asymptotic learning error bounds under non-convex settings, which are tighter than those reported in existing works. For the privacy analysis, we adopt the notion of concentrated geo-privacy, which quantifies privacy preservation based on the Euclidean distance between inputs. We demonstrate that it enables an improved trade-off between privacy preservation and model accuracy compared to differential privacy. Finally, numerical simulations validate our theoretical results.

No-regret Exploration in Shuffle Private Reinforcement Learning

Differential privacy (DP) has recently been introduced into episodic reinforcement learning (RL) to formally address user privacy concerns in personalized services. Previous work mainly focuses on two trust models of DP: the central model, where a central agent is responsible for protecting users' sensitive data, and the (stronger) local model, where the protection occurs directly on the user side. However, they either require a trusted central agent or incur a significantly higher privacy cost, making it unsuitable for many scenarios. This work introduces a trust model stronger than the central model but with a lower privacy cost than the local model, leveraging the emerging \emph{shuffle} model of privacy. We present the first generic algorithm for episodic RL under the shuffle model, where a trusted shuffler randomly permutes a batch of users' data before sending it to the central agent. We then instantiate the algorithm using our proposed shuffle Privatizer, relying on a shuffle private binary summation mechanism. Our analysis shows that the algorithm achieves a near-optimal regret bound comparable to that of the centralized model and significantly outperforms the local model in terms of privacy cost.

BreakNet: Discontinuity-Resilient Multi-Scale Transformer Segmentation of Retinal Layers

Visible light optical coherence tomography (vis-OCT) is gaining traction for retinal imaging due to its high resolution and functional capabilities. However, the significant absorption of hemoglobin in the visible light range leads to pronounced shadow artifacts from retinal blood vessels, posing challenges for accurate layer segmentation. In this study, we present BreakNet, a multi-scale Transformer-based segmentation model designed to address boundary discontinuities caused by these shadow artifacts. BreakNet utilizes hierarchical Transformer and convolutional blocks to extract multi-scale global and local feature maps, capturing essential contextual, textural, and edge characteristics. The model incorporates decoder blocks that expand pathwaproys to enhance the extraction of fine details and semantic information, ensuring precise segmentation. Evaluated on rodent retinal images acquired with prototype vis-OCT, BreakNet demonstrated superior performance over state-of-the-art segmentation models, such as TCCT-BP and U-Net, even when faced with limited-quality ground truth data. Our findings indicate that BreakNet has the potential to significantly improve retinal quantification and analysis.

Fully Automated OCT-based Tissue Screening System

This study introduces a groundbreaking optical coherence tomography (OCT) imaging system dedicated for high-throughput screening applications using ex vivo tissue culture. Leveraging OCT's non-invasive, high-resolution capabilities, the system is equipped with a custom-designed motorized platform and tissue detection ability for automated, successive imaging across samples. Transformer-based deep learning segmentation algorithms further ensure robust, consistent, and efficient readouts meeting the standards for screening assays. Validated using retinal explant cultures from a mouse model of retinal degeneration, the system provides robust, rapid, reliable, unbiased, and comprehensive readouts of tissue response to treatments. This fully automated OCT-based system marks a significant advancement in tissue screening, promising to transform drug discovery, as well as other relevant research fields.