Speech as a Biomarker for Disease Detection

Speech is a rich biomarker that encodes substantial information about the health of a speaker, and thus it has been proposed for the detection of numerous diseases, achieving promising results. However, questions remain about what the models trained for the automatic detection of these diseases are actually learning and the basis for their predictions, which can significantly impact patients' lives. This work advocates for an interpretable health model, suitable for detecting several diseases, motivated by the observation that speech-affecting disorders often have overlapping effects on speech signals. A framework is presented that first defines "reference speech" and then leverages this definition for disease detection. Reference speech is characterized through reference intervals, i.e., the typical values of clinically meaningful acoustic and linguistic features derived from a reference population. This novel approach in the field of speech as a biomarker is inspired by the use of reference intervals in clinical laboratory science. Deviations of new speakers from this reference model are quantified and used as input to detect Alzheimer's and Parkinson's disease. The classification strategy explored is based on Neural Additive Models, a type of glass-box neural network, which enables interpretability. The proposed framework for reference speech characterization and disease detection is designed to support the medical community by providing clinically meaningful explanations that can serve as a valuable second opinion.

Pathological speech detection using x-vector embeddings

The potential of speech as a non-invasive biomarker to assess a speaker's health has been repeatedly supported by the results of multiple works, for both physical and psychological conditions. Traditional systems for speech-based disease classification have focused on carefully designed knowledge-based features. However, these features may not represent the disease's full symptomatology, and may even overlook its more subtle manifestations. This has prompted researchers to move in the direction of general speaker representations that inherently model symptoms, such as Gaussian Supervectors, i-vectors and, x-vectors. In this work, we focus on the latter, to assess their applicability as a general feature extraction method to the detection of Parkinson's disease (PD) and obstructive sleep apnea (OSA). We test our approach against knowledge-based features and i-vectors, and report results for two European Portuguese corpora, for OSA and PD, as well as for an additional Spanish corpus for PD. Both x-vector and i-vector models were trained with an out-of-domain European Portuguese corpus. Our results show that x-vectors are able to perform better than knowledge-based features in same-language corpora. Moreover, while x-vectors performed similarly to i-vectors in matched conditions, they significantly outperform them when domain-mismatch occurs.