A generalizable 3D framework and model for self-supervised learning in medical imaging

Current self-supervised learning methods for 3D medical imaging rely on simple pretext formulations and organ- or modality-specific datasets, limiting their generalizability and scalability. We present 3DINO, a cutting-edge SSL method adapted to 3D datasets, and use it to pretrain 3DINO-ViT: a general-purpose medical imaging model, on an exceptionally large, multimodal, and multi-organ dataset of ~100,000 3D medical imaging scans from over 10 organs. We validate 3DINO-ViT using extensive experiments on numerous medical imaging segmentation and classification tasks. Our results demonstrate that 3DINO-ViT generalizes across modalities and organs, including out-of-distribution tasks and datasets, outperforming state-of-the-art methods on the majority of evaluation metrics and labeled dataset sizes. Our 3DINO framework and 3DINO-ViT will be made available to enable research on 3D foundation models or further finetuning for a wide range of medical imaging applications.

Exploiting Domain-Specific Parallel Data on Multilingual Language Models for Low-resource Language Translation

Neural Machine Translation (NMT) systems built on multilingual sequence-to-sequence Language Models (msLMs) fail to deliver expected results when the amount of parallel data for a language, as well as the language's representation in the model are limited. This restricts the capabilities of domain-specific NMT systems for low-resource languages (LRLs). As a solution, parallel data from auxiliary domains can be used either to fine-tune or to further pre-train the msLM. We present an evaluation of the effectiveness of these two techniques in the context of domain-specific LRL-NMT. We also explore the impact of domain divergence on NMT model performance. We recommend several strategies for utilizing auxiliary parallel data in building domain-specific NMT models for LRLs.

Leveraging Auxiliary Domain Parallel Data in Intermediate Task Fine-tuning for Low-resource Translation

NMT systems trained on Pre-trained Multilingual Sequence-Sequence (PMSS) models flounder when sufficient amounts of parallel data is not available for fine-tuning. This specifically holds for languages missing/under-represented in these models. The problem gets aggravated when the data comes from different domains. In this paper, we show that intermediate-task fine-tuning (ITFT) of PMSS models is extremely beneficial for domain-specific NMT, especially when target domain data is limited/unavailable and the considered languages are missing or under-represented in the PMSS model. We quantify the domain-specific results variations using a domain-divergence test, and show that ITFT can mitigate the impact of domain divergence to some extent.