A Chain-Driven, Sandwich-Legged Quadruped Robot: Design and Experimental Analysis

This paper introduces a chain-driven, sandwich-legged, mid-size quadruped robot designed as an accessible research platform. The design prioritizes enhanced locomotion capabilities, improved reliability and safety of the actuation system, and simplified, cost-effective manufacturing processes. Locomotion performance is optimized through a sandwiched leg design and a dual-motor configuration, reducing leg inertia for agile movements. Reliability and safety are achieved by integrating robust cable strain reliefs, efficient heat sinks for motor thermal management, and mechanical limits to restrict leg motion. Simplified design considerations include a quasi-direct drive (QDD) actuator and the adoption of low-cost fabrication techniques, such as laser cutting and 3D printing, to minimize cost and ensure rapid prototyping. The robot weighs approximately 25 kg and is developed at a cost under \$8000, making it a scalable and affordable solution for robotics research. Experimental validations demonstrate the platform's capability to execute trot and crawl gaits on flat terrain and slopes, highlighting its potential as a versatile and reliable quadruped research platform.

Reducing Onboard Processing Time for Path Planning in Dynamically Evolving Polygonal Maps

Autonomous agents face the challenge of coordinating multiple tasks (perception, motion planning, controller) which are computationally expensive on a single onboard computer. To utilize the onboard processing capacity optimally, it is imperative to arrive at computationally efficient algorithms for global path planning. In this work, it is attempted to reduce the processing time for global path planning in dynamically evolving polygonal maps. In dynamic environments, maps may not remain valid for long. Hence it is of utmost importance to obtain the shortest path quickly in an ever-changing environment. To address this, an existing rapid path-finding algorithm, the Minimal Construct was used. This algorithm discovers only a necessary portion of the Visibility Graph around obstacles and computes collision tests only for lines that seem heuristically promising. Simulations show that this algorithm finds shortest paths faster than traditional grid-based A* searches in most cases, resulting in smoother and shorter paths even in dynamic environments.

Machine-Learning Driven Drug Repurposing for COVID-19

The integration of machine learning methods into bioinformatics provides particular benefits in identifying how therapeutics effective in one context might have utility in an unknown clinical context or against a novel pathology. We aim to discover the underlying associations between viral proteins and antiviral therapeutics that are effective against them by employing neural network models. Using the National Center for Biotechnology Information virus protein database and the DrugVirus database, which provides a comprehensive report of broad-spectrum antiviral agents (BSAAs) and viruses they inhibit, we trained ANN models with virus protein sequences as inputs and antiviral agents deemed safe-in-humans as outputs. Model training excluded SARS-CoV-2 proteins and included only Phases II, III, IV and Approved level drugs. Using sequences for SARS-CoV-2 (the coronavirus that causes COVID-19) as inputs to the trained models produces outputs of tentative safe-in-human antiviral candidates for treating COVID-19. Our results suggest multiple drug candidates, some of which complement recent findings from noteworthy clinical studies. Our in-silico approach to drug repurposing has promise in identifying new drug candidates and treatments for other viruses.

SynGAN: Towards Generating Synthetic Network Attacks using GANs

The rapid digital transformation without security considerations has resulted in the rise of global-scale cyberattacks. The first line of defense against these attacks are Network Intrusion Detection Systems (NIDS). Once deployed, however, these systems work as blackboxes with a high rate of false positives with no measurable effectiveness. There is a need to continuously test and improve these systems by emulating real-world network attack mutations. We present SynGAN, a framework that generates adversarial network attacks using the Generative Adversial Networks (GAN). SynGAN generates malicious packet flow mutations using real attack traffic, which can improve NIDS attack detection rates. As a first step, we compare two public datasets, NSL-KDD and CICIDS2017, for generating synthetic Distributed Denial of Service (DDoS) network attacks. We evaluate the attack quality (real vs. synthetic) using a gradient boosting classifier.