Large-scale pre-training has shown remarkable performance in building open-domain dialogue systems. However, previous works mainly focus on showing and evaluating the conversational performance of the released dialogue model, ignoring the discussion of some key factors towards a powerful human-like chatbot, especially in Chinese scenarios. In this paper, we conduct extensive experiments to investigate these under-explored factors, including data quality control, model architecture designs, training approaches, and decoding strategies. We propose EVA2.0, a large-scale pre-trained open-domain Chinese dialogue model with 2.8 billion parameters, and make our models and code publicly available. To our knowledge, EVA2.0 is the largest open-source Chinese dialogue model. Automatic and human evaluations show that our model significantly outperforms other open-source counterparts. We also discuss the limitations of this work by presenting some failure cases and pose some future directions.