Leveraging Prompt Learning and Pause Encoding for Alzheimer's Disease Detection

Compared to other clinical screening techniques, speech-and-language-based automated Alzheimer's disease (AD) detection methods are characterized by their non-invasiveness, cost-effectiveness, and convenience. Previous studies have demonstrated the efficacy of fine-tuning pre-trained language models (PLMs) for AD detection. However, the objective of this traditional fine-tuning method, which involves inputting only transcripts, is inconsistent with the masked language modeling (MLM) task used during the pre-training phase of PLMs. In this paper, we investigate prompt-based fine-tuning of PLMs, converting the classification task into a MLM task by inserting prompt templates into the transcript inputs. We also explore the impact of incorporating pause information from forced alignment into manual transcripts. Additionally, we compare the performance of various automatic speech recognition (ASR) models and select the Whisper model to generate ASR-based transcripts for comparison with manual transcripts. Furthermore, majority voting and ensemble techniques are applied across different PLMs (BERT and RoBERTa) using different random seeds. Ultimately, we obtain maximum detection accuracy of 95.8% (with mean 87.9%, std 3.3%) using manual transcripts, achieving state-of-the-art performance for AD detection using only transcripts on the ADReSS test set.

Clever Hans Effect Found in Automatic Detection of Alzheimer's Disease through Speech

We uncover an underlying bias present in the audio recordings produced from the picture description task of the Pitt corpus, the largest publicly accessible database for Alzheimer's Disease (AD) detection research. Even by solely utilizing the silent segments of these audio recordings, we achieve nearly 100% accuracy in AD detection. However, employing the same methods to other datasets and preprocessed Pitt recordings results in typical levels (approximately 80%) of AD detection accuracy. These results demonstrate a Clever Hans effect in AD detection on the Pitt corpus. Our findings emphasize the crucial importance of maintaining vigilance regarding inherent biases in datasets utilized for training deep learning models, and highlight the necessity for a better understanding of the models' performance.