A Cross Spatio-Temporal Pathology-based Lung Nodule Dataset

Recently, intelligent analysis of lung nodules with the assistant of computer aided detection (CAD) techniques can improve the accuracy rate of lung cancer diagnosis. However, existing CAD systems and pulmonary datasets mainly focus on Computed Tomography (CT) images from one single period, while ignoring the cross spatio-temporal features associated with the progression of nodules contained in imaging data from various captured periods of lung cancer. If the evolution patterns of nodules across various periods in the patients' CT sequences can be explored, it will play a crucial role in guiding the precise screening identification of lung cancer. Therefore, a cross spatio-temporal lung nodule dataset with pathological information for nodule identification and diagnosis is constructed, which contains 328 CT sequences and 362 annotated nodules from 109 patients. This comprehensive database is intended to drive research in the field of CAD towards more practical and robust methods, and also contribute to the further exploration of precision medicine related field. To ensure patient confidentiality, we have removed sensitive information from the dataset.

Probabilistic Guarantees of Stochastic Recursive Gradient in Non-Convex Finite Sum Problems

This paper develops a new dimension-free Azuma-Hoeffding type bound on summation norm of a martingale difference sequence with random individual bounds. With this novel result, we provide high-probability bounds for the gradient norm estimator in the proposed algorithm Prob-SARAH, which is a modified version of the StochAstic Recursive grAdient algoritHm (SARAH), a state-of-art variance reduced algorithm that achieves optimal computational complexity in expectation for the finite sum problem. The in-probability complexity by Prob-SARAH matches the best in-expectation result up to logarithmic factors. Empirical experiments demonstrate the superior probabilistic performance of Prob-SARAH on real datasets compared to other popular algorithms.

Online Bootstrap Inference with Nonconvex Stochastic Gradient Descent Estimator

In this paper, we investigate the theoretical properties of stochastic gradient descent (SGD) for statistical inference in the context of nonconvex optimization problems, which have been relatively unexplored compared to convex settings. Our study is the first to establish provable inferential procedures using the SGD estimator for general nonconvex objective functions, which may contain multiple local minima. We propose two novel online inferential procedures that combine SGD and the multiplier bootstrap technique. The first procedure employs a consistent covariance matrix estimator, and we establish its error convergence rate. The second procedure approximates the limit distribution using bootstrap SGD estimators, yielding asymptotically valid bootstrap confidence intervals. We validate the effectiveness of both approaches through numerical experiments. Furthermore, our analysis yields an intermediate result: the in-expectation error convergence rate for the original SGD estimator in nonconvex settings, which is comparable to existing results for convex problems. We believe this novel finding holds independent interest and enriches the literature on optimization and statistical inference.