J-Invariant Volume Shuffle for Self-Supervised Cryo-Electron Tomogram Denoising on Single Noisy Volume

Cryo-Electron Tomography (Cryo-ET) enables detailed 3D visualization of cellular structures in near-native states but suffers from low signal-to-noise ratio due to imaging constraints. Traditional denoising methods and supervised learning approaches often struggle with complex noise patterns and the lack of paired datasets. Self-supervised methods, which utilize noisy input itself as a target, have been studied; however, existing Cryo-ET self-supervised denoising methods face significant challenges due to losing information during training and the learned incomplete noise patterns. In this paper, we propose a novel self-supervised learning model that denoises Cryo-ET volumetric images using a single noisy volume. Our method features a U-shape J-invariant blind spot network with sparse centrally masked convolutions, dilated channel attention blocks, and volume unshuffle/shuffle technique. The volume-unshuffle/shuffle technique expands receptive fields and utilizes multi-scale representations, significantly improving noise reduction and structural preservation. Experimental results demonstrate that our approach achieves superior performance compared to existing methods, advancing Cryo-ET data processing for structural biology research

FIAS: Feature Imbalance-Aware Medical Image Segmentation with Dynamic Fusion and Mixing Attention

With the growing application of transformer in computer vision, hybrid architecture that combine convolutional neural networks (CNNs) and transformers demonstrates competitive ability in medical image segmentation. However, direct fusion of features from CNNs and transformers often leads to feature imbalance and redundant information. To address these issues, we propose a Feaure Imbalance-Aware Segmentation (FIAS) network, which incorporates a dual-path encoder and a novel Mixing Attention (MixAtt) decoder. The dual-branches encoder integrates a DilateFormer for long-range global feature extraction and a Depthwise Multi-Kernel (DMK) convolution for capturing fine-grained local details. A Context-Aware Fusion (CAF) block dynamically balances the contribution of these global and local features, preventing feature imbalance. The MixAtt decoder further enhances segmentation accuracy by combining self-attention and Monte Carlo attention, enabling the model to capture both small details and large-scale dependencies. Experimental results on the Synapse multi-organ and ACDC datasets demonstrate the strong competitiveness of our approach in medical image segmentation tasks.