CNN-Transformer Rectified Collaborative Learning for Medical Image Segmentation

Automatic and precise medical image segmentation (MIS) is of vital importance for clinical diagnosis and analysis. Current MIS methods mainly rely on the convolutional neural network (CNN) or self-attention mechanism (Transformer) for feature modeling. However, CNN-based methods suffer from the inaccurate localization owing to the limited global dependency while Transformer-based methods always present the coarse boundary for the lack of local emphasis. Although some CNN-Transformer hybrid methods are designed to synthesize the complementary local and global information for better performance, the combination of CNN and Transformer introduces numerous parameters and increases the computation cost. To this end, this paper proposes a CNN-Transformer rectified collaborative learning (CTRCL) framework to learn stronger CNN-based and Transformer-based models for MIS tasks via the bi-directional knowledge transfer between them. Specifically, we propose a rectified logit-wise collaborative learning (RLCL) strategy which introduces the ground truth to adaptively select and rectify the wrong regions in student soft labels for accurate knowledge transfer in the logit space. We also propose a class-aware feature-wise collaborative learning (CFCL) strategy to achieve effective knowledge transfer between CNN-based and Transformer-based models in the feature space by granting their intermediate features the similar capability of category perception. Extensive experiments on three popular MIS benchmarks demonstrate that our CTRCL outperforms most state-of-the-art collaborative learning methods under different evaluation metrics.

M$^{2}$SNet: Multi-scale in Multi-scale Subtraction Network for Medical Image Segmentation

Accurate medical image segmentation is critical for early medical diagnosis. Most existing methods are based on U-shape structure and use element-wise addition or concatenation to fuse different level features progressively in decoder. However, both the two operations easily generate plenty of redundant information, which will weaken the complementarity between different level features, resulting in inaccurate localization and blurred edges of lesions. To address this challenge, we propose a general multi-scale in multi-scale subtraction network (M$^{2}$SNet) to finish diverse segmentation from medical image. Specifically, we first design a basic subtraction unit (SU) to produce the difference features between adjacent levels in encoder. Next, we expand the single-scale SU to the intra-layer multi-scale SU, which can provide the decoder with both pixel-level and structure-level difference information. Then, we pyramidally equip the multi-scale SUs at different levels with varying receptive fields, thereby achieving the inter-layer multi-scale feature aggregation and obtaining rich multi-scale difference information. In addition, we build a training-free network ``LossNet'' to comprehensively supervise the task-aware features from bottom layer to top layer, which drives our multi-scale subtraction network to capture the detailed and structural cues simultaneously. Without bells and whistles, our method performs favorably against most state-of-the-art methods under different evaluation metrics on eleven datasets of four different medical image segmentation tasks of diverse image modalities, including color colonoscopy imaging, ultrasound imaging, computed tomography (CT), and optical coherence tomography (OCT). The source code can be available at \url{https://github.com/Xiaoqi-Zhao-DLUT/MSNet}.