ADM: Accelerated Diffusion Model via Estimated Priors for Robust Motion Prediction under Uncertainties

Motion prediction is a challenging problem in autonomous driving as it demands the system to comprehend stochastic dynamics and the multi-modal nature of real-world agent interactions. Diffusion models have recently risen to prominence, and have proven particularly effective in pedestrian motion prediction tasks. However, the significant time consumption and sensitivity to noise have limited the real-time predictive capability of diffusion models. In response to these impediments, we propose a novel diffusion-based, acceleratable framework that adeptly predicts future trajectories of agents with enhanced resistance to noise. The core idea of our model is to learn a coarse-grained prior distribution of trajectory, which can skip a large number of denoise steps. This advancement not only boosts sampling efficiency but also maintains the fidelity of prediction accuracy. Our method meets the rigorous real-time operational standards essential for autonomous vehicles, enabling prompt trajectory generation that is vital for secure and efficient navigation. Through extensive experiments, our method speeds up the inference time to 136ms compared to standard diffusion model, and achieves significant improvement in multi-agent motion prediction on the Argoverse 1 motion forecasting dataset.

PathoDuet: Foundation Models for Pathological Slide Analysis of H&E and IHC Stains

Large amounts of digitized histopathological data display a promising future for developing pathological foundation models via self-supervised learning methods. Foundation models pretrained with these methods serve as a good basis for downstream tasks. However, the gap between natural and histopathological images hinders the direct application of existing methods. In this work, we present PathoDuet, a series of pretrained models on histopathological images, and a new self-supervised learning framework in histopathology. The framework is featured by a newly-introduced pretext token and later task raisers to explicitly utilize certain relations between images, like multiple magnifications and multiple stains. Based on this, two pretext tasks, cross-scale positioning and cross-stain transferring, are designed to pretrain the model on Hematoxylin and Eosin (H\&E) images and transfer the model to immunohistochemistry (IHC) images, respectively. To validate the efficacy of our models, we evaluate the performance over a wide variety of downstream tasks, including patch-level colorectal cancer subtyping and whole slide image (WSI)-level classification in H\&E field, together with expression level prediction of IHC marker and tumor identification in IHC field. The experimental results show the superiority of our models over most tasks and the efficacy of proposed pretext tasks. The codes and models are available at https://github.com/openmedlab/PathoDuet.