CT to PET Translation: A Large-scale Dataset and Domain-Knowledge-Guided Diffusion Approach

Positron Emission Tomography (PET) and Computed Tomography (CT) are essential for diagnosing, staging, and monitoring various diseases, particularly cancer. Despite their importance, the use of PET/CT systems is limited by the necessity for radioactive materials, the scarcity of PET scanners, and the high cost associated with PET imaging. In contrast, CT scanners are more widely available and significantly less expensive. In response to these challenges, our study addresses the issue of generating PET images from CT images, aiming to reduce both the medical examination cost and the associated health risks for patients. Our contributions are twofold: First, we introduce a conditional diffusion model named CPDM, which, to our knowledge, is one of the initial attempts to employ a diffusion model for translating from CT to PET images. Second, we provide the largest CT-PET dataset to date, comprising 2,028,628 paired CT-PET images, which facilitates the training and evaluation of CT-to-PET translation models. For the CPDM model, we incorporate domain knowledge to develop two conditional maps: the Attention map and the Attenuation map. The former helps the diffusion process focus on areas of interest, while the latter improves PET data correction and ensures accurate diagnostic information. Experimental evaluations across various benchmarks demonstrate that CPDM surpasses existing methods in generating high-quality PET images in terms of multiple metrics. The source code and data samples are available at https://github.com/thanhhff/CPDM.

High Accurate and Explainable Multi-Pill Detection Framework with Graph Neural Network-Assisted Multimodal Data Fusion

Due to the significant resemblance in visual appearance, pill misuse is prevalent and has become a critical issue, responsible for one-third of all deaths worldwide. Pill identification, thus, is a crucial concern needed to be investigated thoroughly. Recently, several attempts have been made to exploit deep learning to tackle the pill identification problem. However, most published works consider only single-pill identification and fail to distinguish hard samples with identical appearances. Also, most existing pill image datasets only feature single pill images captured in carefully controlled environments under ideal lighting conditions and clean backgrounds. In this work, we are the first to tackle the multi-pill detection problem in real-world settings, aiming at localizing and identifying pills captured by users in a pill intake. Moreover, we also introduce a multi-pill image dataset taken in unconstrained conditions. To handle hard samples, we propose a novel method for constructing heterogeneous a priori graphs incorporating three forms of inter-pill relationships, including co-occurrence likelihood, relative size, and visual semantic correlation. We then offer a framework for integrating a priori with pills' visual features to enhance detection accuracy. Our experimental results have proved the robustness, reliability, and explainability of the proposed framework. Experimentally, it outperforms all detection benchmarks in terms of all evaluation metrics. Specifically, our proposed framework improves COCO mAP metrics by 9.4% over Faster R-CNN and 12.0% compared to vanilla YOLOv5. Our study opens up new opportunities for protecting patients from medication errors using an AI-based pill identification solution.