"Some other poor soul's problems": a peer recommendation intervention for health-related social support

Online health communities (OHCs) offer the promise of connecting with supportive peers. Forming these connections first requires finding relevant peers - a process that can be time-consuming. Peer recommendation systems are a computational approach to make finding peers easier during a health journey. By encouraging OHC users to alter their online social networks, peer recommendations could increase available support. But these benefits are hypothetical and based on mixed, observational evidence. To experimentally evaluate the effect of peer recommendations, we conceptualize these systems as health interventions designed to increase specific beneficial connection behaviors. In this paper, we designed a peer recommendation intervention to increase two behaviors: reading about peer experiences and interacting with peers. We conducted an initial feasibility assessment of this intervention by conducting a 12-week field study in which 79 users of CaringBridge received weekly peer recommendations via email. Our results support the usefulness and demand for peer recommendation and suggest benefits to evaluating larger peer recommendation interventions. Our contributions include practical guidance on the development and evaluation of peer recommendation interventions for OHCs.

Differentiable Electron Microscopy Simulation: Methods and Applications for Visualization

We propose a new microscopy simulation system that can depict atomistic models in a micrograph visual style, similar to results of physical electron microscopy imaging. This system is scalable, able to represent simulation of electron microscopy of tens of viral particles and synthesizes the image faster than previous methods. On top of that, the simulator is differentiable, both its deterministic as well as stochastic stages that form signal and noise representations in the micrograph. This notable property has the capability for solving inverse problems by means of optimization and thus allows for generation of microscopy simulations using the parameter settings estimated from real data. We demonstrate this learning capability through two applications: (1) estimating the parameters of the modulation transfer function defining the detector properties of the simulated and real micrographs, and (2) denoising the real data based on parameters trained from the simulated examples. While current simulators do not support any parameter estimation due to their forward design, we show that the results obtained using estimated parameters are very similar to the results of real micrographs. Additionally, we evaluate the denoising capabilities of our approach and show that the results showed an improvement over state-of-the-art methods. Denoised micrographs exhibit less noise in the tilt-series tomography reconstructions, ultimately reducing the visual dominance of noise in direct volume rendering of microscopy tomograms.