Toward Robotically Automated Femoral Vascular Access

Advanced resuscitative technologies, such as Extra Corporeal Membrane Oxygenation (ECMO) cannulation or Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA), are technically difficult even for skilled medical personnel. This paper describes the core technologies that comprise a teleoperated system capable of granting femoral vascular access, which is an important step in both of these procedures and a major roadblock in their wider use in the field. These technologies include a kinematic manipulator, various sensing modalities, and a user interface. In addition, we evaluate our system on a surgical phantom as well as in-vivo porcine experiments. These resulted in, to the best of our knowledge, the first robot-assisted arterial catheterizations; a major step towards our eventual goal of automatic catheter insertion through the Seldinger technique.

Detecting Patterns of Physiological Response to Hemodynamic Stress via Unsupervised Deep Learning

Monitoring physiological responses to hemodynamic stress can help in determining appropriate treatment and ensuring good patient outcomes. Physicians' intuition suggests that the human body has a number of physiological response patterns to hemorrhage which escalate as blood loss continues, however the exact etiology and phenotypes of such responses are not well known or understood only at a coarse level. Although previous research has shown that machine learning models can perform well in hemorrhage detection and survival prediction, it is unclear whether machine learning could help to identify and characterize the underlying physiological responses in raw vital sign data. We approach this problem by first transforming the high-dimensional vital sign time series into a tractable, lower-dimensional latent space using a dilated, causal convolutional encoder model trained purely unsupervised. Second, we identify informative clusters in the embeddings. By analyzing the clusters of latent embeddings and visualizing them over time, we hypothesize that the clusters correspond to the physiological response patterns that match physicians' intuition. Furthermore, we attempt to evaluate the latent embeddings using a variety of methods, such as predicting the cluster labels using explainable features.