SpecPCM: A Low-power PCM-based In-Memory Computing Accelerator for Full-stack Mass Spectrometry Analysis

Mass spectrometry (MS) is essential for proteomics and metabolomics but faces impending challenges in efficiently processing the vast volumes of data. This paper introduces SpecPCM, an in-memory computing (IMC) accelerator designed to achieve substantial improvements in energy and delay efficiency for both MS spectral clustering and database (DB) search. SpecPCM employs analog processing with low-voltage swing and utilizes recently introduced phase change memory (PCM) devices based on superlattice materials, optimized for low-voltage and low-power programming. Our approach integrates contributions across multiple levels: application, algorithm, circuit, device, and instruction sets. We leverage a robust hyperdimensional computing (HD) algorithm with a novel dimension-packing method and develop specialized hardware for the end-to-end MS pipeline to overcome the non-ideal behavior of PCM devices. We further optimize multi-level PCM devices for different tasks by using different materials. We also perform a comprehensive design exploration to improve energy and delay efficiency while maintaining accuracy, exploring various combinations of hardware and software parameters controlled by the instruction set architecture (ISA). SpecPCM, with up to three bits per cell, achieves speedups of up to 82x and 143x for MS clustering and DB search tasks, respectively, along with a four-orders-of-magnitude improvement in energy efficiency compared with state-of-the-art CPU/GPU tools.

FSL-HDnn: A 5.7 TOPS/W End-to-end Few-shot Learning Classifier Accelerator with Feature Extraction and Hyperdimensional Computing

This paper introduces FSL-HDnn, an energy-efficient accelerator that implements the end-to-end pipeline of feature extraction, classification, and on-chip few-shot learning (FSL) through gradient-free learning techniques in a 40 nm CMOS process. At its core, FSL-HDnn integrates two low-power modules: Weight clustering feature extractor and Hyperdimensional Computing (HDC). Feature extractor utilizes advanced weight clustering and pattern reuse strategies for optimized CNN-based feature extraction. Meanwhile, HDC emerges as a novel approach for lightweight FSL classifier, employing hyperdimensional vectors to improve training accuracy significantly compared to traditional distance-based approaches. This dual-module synergy not only simplifies the learning process by eliminating the need for complex gradients but also dramatically enhances energy efficiency and performance. Specifically, FSL-HDnn achieves an Intensity unprecedented energy efficiency of 5.7 TOPS/W for feature 1 extraction and 0.78 TOPS/W for classification and learning Training Intensity phases, achieving improvements of 2.6X and 6.6X, respectively, Storage over current state-of-the-art CNN and FSL processors.