MRI Contrast Enhancement Kinetics World Model

Clinical MRI contrast acquisition suffers from inefficient information yield, which presents as a mismatch between the risky and costly acquisition protocol and the fixed and sparse acquisition sequence. Applying world models to simulate the contrast enhancement kinetics in the human body enables continuous contrast-free dynamics. However, the low temporal resolution in MRI acquisition restricts the training of world models, leading to a sparsely sampled dataset. Directly training a generative model to capture the kinetics leads to two limitations: (a) Due to the absence of data on missing time, the model tends to overfit to irrelevant features, leading to content distortion. (b) Due to the lack of continuous temporal supervision, the model fails to learn the continuous kinetics law over time, causing temporal discontinuities. For the first time, we propose MRI Contrast Enhancement Kinetics World model (MRI CEKWorld) with SpatioTemporal Consistency Learning (STCL). For (a), guided by the spatial law that patient-level structures remain consistent during enhancement, we propose Latent Alignment Learning (LAL) that constructs a patient-specific template to constrain contents to align with this template. For (b), guided by the temporal law that the kinetics follow a consistent smooth trend, we propose Latent Difference Learning (LDL) which extends the unobserved intervals by interpolation and constrains smooth variations in the latent space among interpolated sequences. Extensive experiments on two datasets show our MRI CEKWorld achieves better realistic contents and kinetics. Codes will be available at https://github.com/DD0922/MRI-Contrast-Enhancement-Kinetics-World-Model.

Predicting Preschoolers' Externalizing Problems with Mother-Child Interaction Dynamics and Deep Learning

Objective: Predicting children's future levels of externalizing problems helps to identify children at risk and guide targeted prevention. Existing studies have shown that mothers providing support in response to children's dysregulation was associated with children's lower levels of externalizing problems. The current study aims to evaluate and improve the accuracy of predicting children's externalizing problems with mother-child interaction dynamics. Method: This study used mother-child interaction dynamics during a challenging puzzle task to predict children's externalizing problems six months later (N=101, 46 boys, Mage=57.41 months, SD=6.58). Performance of the Residual Dynamic Structural Equation Model (RDSEM) was compared with the Attention-based Sequential Behavior Interaction Modeling (ASBIM) model, developed using the deep learning techniques. Results: The RDSEM revealed that children whose mothers provided more autonomy support after increases of child defeat had lower levels of externalizing problems. Five-fold cross-validation showed that the RDSEM had good prediction accuracy. The ASBIM model further improved prediction accuracy, especially after including child inhibitory control as a personalized individual feature. Conclusions: The dynamic process of mother-child interaction provides important information for predicting children's externalizing problems, especially maternal autonomy supportive response to child defeat. The deep learning model is a useful tool to further improve prediction accuracy.

JCCS-PFGM: A Novel Circle-Supervision based Poisson Flow Generative Model for Multiphase CECT Progressive Low-Dose Reconstruction with Joint Condition

Multiphase contrast-enhanced computed tomography (CECT) scan is clinically significant to demonstrate the anatomy at different phases. In practice, such a multiphase CECT scan inherently takes longer time and deposits much more radiation dose into a patient body than a regular CT scan, and reduction of the radiation dose typically compromise the CECT image quality and its diagnostic value. With Joint Condition and Circle-Supervision, here we propose a novel Poisson Flow Generative Model (JCCS-PFGM) to promote the progressive low-dose reconstruction for multiphase CECT. JCCS-PFGM is characterized by the following three aspects: a progressive low-dose reconstruction scheme, a circle-supervision strategy, and a joint condition mechanism. Our extensive experiments are performed on a clinical dataset consisting of 11436 images. The results show that our JCCS-PFGM achieves promising PSNR up to 46.3dB, SSIM up to 98.5%, and MAE down to 9.67 HU averagely on phases I, II and III, in quantitative evaluations, as well as gains high-quality readable visualizations in qualitative assessments. All of these findings reveal our method a great potential to be adapted for clinical CECT scans at a much-reduced radiation dose.