MMLNB: Multi-Modal Learning for Neuroblastoma Subtyping Classification Assisted with Textual Description Generation

Neuroblastoma (NB), a leading cause of childhood cancer mortality, exhibits significant histopathological variability, necessitating precise subtyping for accurate prognosis and treatment. Traditional diagnostic methods rely on subjective evaluations that are time-consuming and inconsistent. To address these challenges, we introduce MMLNB, a multi-modal learning (MML) model that integrates pathological images with generated textual descriptions to improve classification accuracy and interpretability. The approach follows a two-stage process. First, we fine-tune a Vision-Language Model (VLM) to enhance pathology-aware text generation. Second, the fine-tuned VLM generates textual descriptions, using a dual-branch architecture to independently extract visual and textual features. These features are fused via Progressive Robust Multi-Modal Fusion (PRMF) Block for stable training. Experimental results show that the MMLNB model is more accurate than the single modal model. Ablation studies demonstrate the importance of multi-modal fusion, fine-tuning, and the PRMF mechanism. This research creates a scalable AI-driven framework for digital pathology, enhancing reliability and interpretability in NB subtyping classification. Our source code is available at https://github.com/HovChen/MMLNB.

Smart Audit System Empowered by LLM

Manufacturing quality audits are pivotal for ensuring high product standards in mass production environments. Traditional auditing processes, however, are labor-intensive and reliant on human expertise, posing challenges in maintaining transparency, accountability, and continuous improvement across complex global supply chains. To address these challenges, we propose a smart audit system empowered by large language models (LLMs). Our approach introduces three innovations: a dynamic risk assessment model that streamlines audit procedures and optimizes resource allocation; a manufacturing compliance copilot that enhances data processing, retrieval, and evaluation for a self-evolving manufacturing knowledge base; and a Re-act framework commonality analysis agent that provides real-time, customized analysis to empower engineers with insights for supplier improvement. These enhancements elevate audit efficiency and effectiveness, with testing scenarios demonstrating an improvement of over 24%.