Digital Twin Generators for Disease Modeling

A patient's digital twin is a computational model that describes the evolution of their health over time. Digital twins have the potential to revolutionize medicine by enabling individual-level computer simulations of human health, which can be used to conduct more efficient clinical trials or to recommend personalized treatment options. Due to the overwhelming complexity of human biology, machine learning approaches that leverage large datasets of historical patients' longitudinal health records to generate patients' digital twins are more tractable than potential mechanistic models. In this manuscript, we describe a neural network architecture that can learn conditional generative models of clinical trajectories, which we call Digital Twin Generators (DTGs), that can create digital twins of individual patients. We show that the same neural network architecture can be trained to generate accurate digital twins for patients across 13 different indications simply by changing the training set and tuning hyperparameters. By introducing a general purpose architecture, we aim to unlock the ability to scale machine learning approaches to larger datasets and across more indications so that a digital twin could be created for any patient in the world.

NuPlan: A closed-loop ML-based planning benchmark for autonomous vehicles

In this work, we propose the world's first closed-loop ML-based planning benchmark for autonomous driving. While there is a growing body of ML-based motion planners, the lack of established datasets and metrics has limited the progress in this area. Existing benchmarks for autonomous vehicle motion prediction have focused on short-term motion forecasting, rather than long-term planning. This has led previous works to use open-loop evaluation with L2-based metrics, which are not suitable for fairly evaluating long-term planning. Our benchmark overcomes these limitations by introducing a large-scale driving dataset, lightweight closed-loop simulator, and motion-planning-specific metrics. We provide a high-quality dataset with 1500h of human driving data from 4 cities across the US and Asia with widely varying traffic patterns (Boston, Pittsburgh, Las Vegas and Singapore). We will provide a closed-loop simulation framework with reactive agents and provide a large set of both general and scenario-specific planning metrics. We plan to release the dataset at NeurIPS 2021 and organize benchmark challenges starting in early 2022.