In this paper, we introduce DINO-X, which is a unified object-centric vision model developed by IDEA Research with the best open-world object detection performance to date. DINO-X employs the same Transformer-based encoder-decoder architecture as Grounding DINO 1.5 to pursue an object-level representation for open-world object understanding. To make long-tailed object detection easy, DINO-X extends its input options to support text prompt, visual prompt, and customized prompt. With such flexible prompt options, we develop a universal object prompt to support prompt-free open-world detection, making it possible to detect anything in an image without requiring users to provide any prompt. To enhance the model's core grounding capability, we have constructed a large-scale dataset with over 100 million high-quality grounding samples, referred to as Grounding-100M, for advancing the model's open-vocabulary detection performance. Pre-training on such a large-scale grounding dataset leads to a foundational object-level representation, which enables DINO-X to integrate multiple perception heads to simultaneously support multiple object perception and understanding tasks, including detection, segmentation, pose estimation, object captioning, object-based QA, etc. Experimental results demonstrate the superior performance of DINO-X. Specifically, the DINO-X Pro model achieves 56.0 AP, 59.8 AP, and 52.4 AP on the COCO, LVIS-minival, and LVIS-val zero-shot object detection benchmarks, respectively. Notably, it scores 63.3 AP and 56.5 AP on the rare classes of LVIS-minival and LVIS-val benchmarks, both improving the previous SOTA performance by 5.8 AP. Such a result underscores its significantly improved capacity for recognizing long-tailed objects.