Traffic signal control (TSC) is a promising low-cost measure to enhance transportation efficiency without affecting existing road infrastructure. While various reinforcement learning-based TSC methods have been proposed and experimentally outperform conventional rule-based methods, none of them has been deployed in the real world. An essential gap lies in the oversimplification of the scenarios in terms of intersection heterogeneity and road network intricacy. To make TSC applicable in urban traffic management, we target TSC coordination in city-scale high-authenticity road networks, aiming to solve the three unique and important challenges: city-level scalability, heterogeneity of real-world intersections, and effective coordination among intricate neighbor connections. Since optimizing multiple agents in a parameter-sharing paradigm can boost the training efficiency and help achieve scalability, we propose our method, CityLight, based on the well-acknowledged optimization framework, parameter-sharing MAPPO. To ensure the unified policy network can learn to fit large-scale heterogeneous intersections and tackle the intricate between-neighbor coordination, CityLight proposes a universal representation module that consists of two key designs: heterogeneous intersection alignment and neighborhood impact alignment for coordination. To further boost coordination, CityLight adopts neighborhood-integrated rewards to transition from achieving local optimal to global optimal. Extensive experiments on datasets with hundreds to tens of thousands of real-world intersections and authentic traffic demands validate the surprising effectiveness and generalizability of CityLight, with an overall performance gain of 11.66% and a 22.59% improvement in transfer scenarios in terms of throughput.