Target-Balanced Score Distillation

Score Distillation Sampling (SDS) enables 3D asset generation by distilling priors from pretrained 2D text-to-image diffusion models, but vanilla SDS suffers from over-saturation and over-smoothing. To mitigate this issue, recent variants have incorporated negative prompts. However, these methods face a critical trade-off: limited texture optimization, or significant texture gains with shape distortion. In this work, we first conduct a systematic analysis and reveal that this trade-off is fundamentally governed by the utilization of the negative prompts, where Target Negative Prompts (TNP) that embed target information in the negative prompts dramatically enhancing texture realism and fidelity but inducing shape distortions. Informed by this key insight, we introduce the Target-Balanced Score Distillation (TBSD). It formulates generation as a multi-objective optimization problem and introduces an adaptive strategy that effectively resolves the aforementioned trade-off. Extensive experiments demonstrate that TBSD significantly outperforms existing state-of-the-art methods, yielding 3D assets with high-fidelity textures and geometrically accurate shape.

DeshadowGAN: A Deep Learning Approach to Remove Shadows from Optical Coherence Tomography Images

Purpose: To remove retinal shadows from optical coherence tomography (OCT) images of the optic nerve head(ONH). Methods:2328 OCT images acquired through the center of the ONH using a Spectralis OCT machine for both eyes of 13 subjects were used to train a generative adversarial network (GAN) using a custom loss function. Image quality was assessed qualitatively (for artifacts) and quantitatively using the intralayer contrast: a measure of shadow visibility ranging from 0 (shadow-free) to 1 (strong shadow) and compared to compensated images. This was computed in the Retinal Nerve Fiber Layer (RNFL), the Inner Plexiform Layer (IPL), the Photoreceptor layer (PR) and the Retinal Pigment Epithelium (RPE) layers. Results: Output images had improved intralayer contrast in all ONH tissue layers. On average the intralayer contrast decreased by 33.7$\pm$6.81%, 28.8$\pm$10.4%, 35.9$\pm$13.0%, and43.0$\pm$19.5%for the RNFL, IPL, PR, and RPE layers respectively, indicating successful shadow removal across all depths. This compared to 70.3$\pm$22.7%, 33.9$\pm$11.5%, 47.0$\pm$11.2%, 26.7$\pm$19.0%for compensation. Output images were also free from artifacts commonly observed with compensation. Conclusions: DeshadowGAN significantly corrected blood vessel shadows in OCT images of the ONH. Our algorithm may be considered as a pre-processing step to improve the performance of a wide range of algorithms including those currently being used for OCT image segmentation, denoising, and classification. Translational Relevance: DeshadowGAN could be integrated to existing OCT devices to improve the diagnosis and prognosis of ocular pathologies.