MPLite: Multi-Aspect Pretraining for Mining Clinical Health Records

The adoption of digital systems in healthcare has resulted in the accumulation of vast electronic health records (EHRs), offering valuable data for machine learning methods to predict patient health outcomes. However, single-visit records of patients are often neglected in the training process due to the lack of annotations of next-visit information, thereby limiting the predictive and expressive power of machine learning models. In this paper, we present a novel framework MPLite that utilizes Multi-aspect Pretraining with Lab results through a light-weight neural network to enhance medical concept representation and predict future health outcomes of individuals. By incorporating both structured medical data and additional information from lab results, our approach fully leverages patient admission records. We design a pretraining module that predicts medical codes based on lab results, ensuring robust prediction by fusing multiple aspects of features. Our experimental evaluation using both MIMIC-III and MIMIC-IV datasets demonstrates improvements over existing models in diagnosis prediction and heart failure prediction tasks, achieving a higher weighted-F1 and recall with MPLite. This work reveals the potential of integrating diverse aspects of data to advance predictive modeling in healthcare.

DeCaf: A Causal Decoupling Framework for OOD Generalization on Node Classification

Graph Neural Networks (GNNs) are susceptible to distribution shifts, creating vulnerability and security issues in critical domains. There is a pressing need to enhance the generalizability of GNNs on out-of-distribution (OOD) test data. Existing methods that target learning an invariant (feature, structure)-label mapping often depend on oversimplified assumptions about the data generation process, which do not adequately reflect the actual dynamics of distribution shifts in graphs. In this paper, we introduce a more realistic graph data generation model using Structural Causal Models (SCMs), allowing us to redefine distribution shifts by pinpointing their origins within the generation process. Building on this, we propose a casual decoupling framework, DeCaf, that independently learns unbiased feature-label and structure-label mappings. We provide a detailed theoretical framework that shows how our approach can effectively mitigate the impact of various distribution shifts. We evaluate DeCaf across both real-world and synthetic datasets that demonstrate different patterns of shifts, confirming its efficacy in enhancing the generalizability of GNNs.

A Topology-aware Graph Coarsening Framework for Continual Graph Learning

Continual learning on graphs tackles the problem of training a graph neural network (GNN) where graph data arrive in a streaming fashion and the model tends to forget knowledge from previous tasks when updating with new data. Traditional continual learning strategies such as Experience Replay can be adapted to streaming graphs, however, these methods often face challenges such as inefficiency in preserving graph topology and incapability of capturing the correlation between old and new tasks. To address these challenges, we propose TA$\mathbb{CO}$, a (t)opology-(a)ware graph (co)arsening and (co)ntinual learning framework that stores information from previous tasks as a reduced graph. At each time period, this reduced graph expands by combining with a new graph and aligning shared nodes, and then it undergoes a "zoom out" process by reduction to maintain a stable size. We design a graph coarsening algorithm based on node representation proximities to efficiently reduce a graph and preserve topological information. We empirically demonstrate the learning process on the reduced graph can approximate that of the original graph. Our experiments validate the effectiveness of the proposed framework on three real-world datasets using different backbone GNN models.