Comorbidity-Informed Transfer Learning for Neuro-developmental Disorder Diagnosis

Neuro-developmental disorders are manifested as dysfunctions in cognition, communication, behaviour and adaptability, and deep learning-based computer-aided diagnosis (CAD) can alleviate the increasingly strained healthcare resources on neuroimaging. However, neuroimaging such as fMRI contains complex spatio-temporal features, which makes the corresponding representations susceptible to a variety of distractions, thus leading to less effective in CAD. For the first time, we present a Comorbidity-Informed Transfer Learning(CITL) framework for diagnosing neuro-developmental disorders using fMRI. In CITL, a new reinforced representation generation network is proposed, which first combines transfer learning with pseudo-labelling to remove interfering patterns from the temporal domain of fMRI and generates new representations using encoder-decoder architecture. The new representations are then trained in an architecturally simple classification network to obtain CAD model. In particular, the framework fully considers the comorbidity mechanisms of neuro-developmental disorders and effectively integrates them with semi-supervised learning and transfer learning, providing new perspectives on interdisciplinary. Experimental results demonstrate that CITL achieves competitive accuracies of 76.32% and 73.15% for detecting autism spectrum disorder and attention deficit hyperactivity disorder, respectively, which outperforms existing related transfer learning work for 7.2% and 0.5% respectively.

A Confounding Factors-Inhibition Adversarial Learning Framework for Multi-site fMRI Mental Disorder Identification

In open data sets of functional magnetic resonance imaging (fMRI), the heterogeneity of the data is typically attributed to a combination of factors, including differences in scanning procedures, the presence of confounding effects, and population diversities between multiple sites. These factors contribute to the diminished effectiveness of representation learning, which in turn affects the overall efficacy of subsequent classification procedures. To address these limitations, we propose a novel multi-site adversarial learning network (MSalNET) for fMRI-based mental disorder detection. Firstly, a representation learning module is introduced with a node information assembly (NIA) mechanism to better extract features from functional connectivity (FC). This mechanism aggregates edge information from both horizontal and vertical directions, effectively assembling node information. Secondly, to generalize the feature across sites, we proposed a site-level feature extraction module that can learn from individual FC data, which circumvents additional prior information. Lastly, an adversarial learning network is proposed as a means of balancing the trade-off between individual classification and site regression tasks, with the introduction of a novel loss function. The proposed method was evaluated on two multi-site fMRI datasets, i.e., Autism Brain Imaging Data Exchange (ABIDE) and ADHD-200. The results indicate that the proposed method achieves a better performance than other related algorithms with the accuracy of 75.56 and 68.92 in ABIDE and ADHD-200 datasets, respectively. Furthermore, the result of the site regression indicates that the proposed method reduces site variability from a data-driven perspective. The most discriminative brain regions revealed by NIA are consistent with statistical findings, uncovering the "black box" of deep learning to a certain extent.