Molecular Signal Reception in Complex Vessel Networks: The Role of the Network Topology

The notion of synthetic molecular communication (MC) refers to the transmission of information via molecules and is largely foreseen for use within the human body, where traditional electromagnetic wave (EM)-based communication is impractical. MC is anticipated to enable innovative medical applications, such as early-stage tumor detection, targeted drug delivery, and holistic approaches like the Internet of Bio-Nano Things (IoBNT). Many of these applications involve parts of the human cardiovascular system (CVS), here referred to as networks, posing challenges for MC due to their complex, highly branched vessel structures. To gain a better understanding of how the topology of such branched vessel networks affects the reception of a molecular signal at a target location, e.g., the network outlet, we present a generic analytical end-to-end model that characterizes molecule propagation and reception in linear branched vessel networks (LBVNs). We specialize this generic model to any MC system employing superparamagnetic iron-oxide nanoparticles (SPIONs) as signaling molecules and a planar coil as receiver (RX). By considering components that have been previously established in testbeds, we effectively isolate the impact of the network topology and validate our theoretical model with testbed data. Additionally, we propose two metrics, namely the molecule delay and the multi-path spread, that relate the LBVN topology to the molecule dispersion induced by the network, thereby linking the network structure to the signal-to-noise ratio (SNR) at the target location. This allows the characterization of the SNR at any point in the network solely based on the network topology. Consequently, our framework can, e.g., be exploited for optimal sensor placement in the CVS or identification of suitable testbed topologies for given SNR requirements.

User Tracking and Direction Estimation Codebook Design for IRS-Assisted mmWave Communication

Future communication systems are envisioned to employ intelligent reflecting surfaces (IRSs) and the millimeter wave (mmWave) frequency band to provide reliable high-rate services. For mobile users, the time-varying channel state information (CSI) requires adequate adjustment of the reflection pattern of the IRS. We propose a novel codebook-based user tracking (UT) algorithm for IRS-assisted mmWave communication, allowing suitable reconfiguration of the IRS unit cell phase shifts, resulting in a high reflection gain. The presented algorithm acquires the direction information of the user based on a peak likelihood-based direction estimation. Using the direction information, the user's trajectory is extrapolated to proactively update the adopted codeword and adjust the IRS phase shift configuration accordingly. Furthermore, we conduct a theoretical analysis of the direction estimation error and utilize the obtained insights to design a codebook specifically optimized for direction estimation. Our numerical results reveal a lower direction estimation error of the proposed UT algorithm when employing our designed codebook compared to codebooks from the literature. Furthermore, the average achieved signal-to-noise ratio (SNR) as well as the average effective rate of the proposed UT algorithm are analyzed. The proposed UT algorithm requires only a low overhead for direction and channel estimation and avoids outdated IRS phase shifts. Furthermore, it is shown to outperform two benchmark schemes based on direct phase shift optimization and hierarchical codebook search, respectively, via computer simulations.

Joint Transmit Signal and Beamforming Design for Integrated Sensing and Power Transfer Systems

Integrating different functionalities, conventionally implemented as dedicated systems, into a single platform allows utilising the available resources more efficiently. We consider an integrated sensing and power transfer (ISAPT) system and propose the joint optimisation of the rectangular pulse-shaped transmit signal and the beamforming vector to combine sensing and wireless power transfer (WPT) functionalities efficiently. In contrast to prior works, we adopt an accurate non-linear circuit-based energy harvesting (EH) model. We formulate and solve a non-convex optimisation problem for a general number of EH receivers to maximise a weighted sum of the average harvested powers at the EH receivers while ensuring the received echo signal reflected by a sensing target (ST) has sufficient power for estimating the range to the ST with a prescribed accuracy within the considered coverage region. The average harvested power is shown to monotonically increase with the pulse duration when the average transmit power budget is sufficiently large. We discuss the trade-off between sensing performance and power transfer for the considered ISAPT system. The proposed approach significantly outperforms a heuristic baseline scheme based on a linear EH model, which linearly combines energy beamforming with the beamsteering vector in the direction to the ST as its transmit strategy.

Microparticle-based Controlled Drug Delivery Systems: From Experiments to Statistical Analysis and Design

Controlled drug delivery (CDD), the controlled release and delivery of therapeutic drugs inside the human body, is a promising approach to increase the efficacy of drug administration and reduce harmful side effects to the body. CDD has been a major research focus in the field of molecular communications (MC) with the goal to aid the design and optimization of CDD systems with communication theoretical analysis. However, the existing studies of CDD under the MC framework are purely theoretical, and the potential of MC for the development of practical CDD applications remains yet to be shown. This paper presents a step towards filling this research gap. Specifically, we present a novel MC-based model for a specific CDD system in which drugs are embedded into microparticles and released gradually towards the target site. It is demonstrated that the proposed model is able to faithfully reproduce experimental data. Furthermore, statistical analysis is conducted to explore the impact of the microparticle size on the drug release. The presented results reveal the sensitivity of the drug release to changes in the microparticle size. In this way, the proposed model can be used for the design of future microparticle-based CDD systems.