Semantic Web and Creative AI -- A Technical Report from ISWS 2023

The International Semantic Web Research School (ISWS) is a week-long intensive program designed to immerse participants in the field. This document reports a collaborative effort performed by ten teams of students, each guided by a senior researcher as their mentor, attending ISWS 2023. Each team provided a different perspective to the topic of creative AI, substantiated by a set of research questions as the main subject of their investigation. The 2023 edition of ISWS focuses on the intersection of Semantic Web technologies and Creative AI. ISWS 2023 explored various intersections between Semantic Web technologies and creative AI. A key area of focus was the potential of LLMs as support tools for knowledge engineering. Participants also delved into the multifaceted applications of LLMs, including legal aspects of creative content production, humans in the loop, decentralised approaches to multimodal generative AI models, nanopublications and AI for personal scientific knowledge graphs, commonsense knowledge in automatic story and narrative completion, generative AI for art critique, prompt engineering, automatic music composition, commonsense prototyping and conceptual blending, and elicitation of tacit knowledge. As Large Language Models and semantic technologies continue to evolve, new exciting prospects are emerging: a future where the boundaries between creative expression and factual knowledge become increasingly permeable and porous, leading to a world of knowledge that is both informative and inspiring.

RNA-KG: An ontology-based knowledge graph for representing interactions involving RNA molecules

The "RNA world" represents a novel frontier for the study of fundamental biological processes and human diseases and is paving the way for the development of new drugs tailored to the patient's biomolecular characteristics. Although scientific data about coding and non-coding RNA molecules are continuously produced and available from public repositories, they are scattered across different databases and a centralized, uniform, and semantically consistent representation of the "RNA world" is still lacking. We propose RNA-KG, a knowledge graph encompassing biological knowledge about RNAs gathered from more than 50 public databases, integrating functional relationships with genes, proteins, and chemicals and ontologically grounded biomedical concepts. To develop RNA-KG, we first identified, pre-processed, and characterized each data source; next, we built a meta-graph that provides an ontological description of the KG by representing all the bio-molecular entities and medical concepts of interest in this domain, as well as the types of interactions connecting them. Finally, we leveraged an instance-based semantically abstracted knowledge model to specify the ontological alignment according to which RNA-KG was generated. RNA-KG can be downloaded in different formats and also queried by a SPARQL endpoint. A thorough topological analysis of the resulting heterogeneous graph provides further insights into the characteristics of the "RNA world". RNA-KG can be both directly explored and visualized, and/or analyzed by applying computational methods to infer bio-medical knowledge from its heterogeneous nodes and edges. The resource can be easily updated with new experimental data, and specific views of the overall KG can be extracted according to the bio-medical problem to be studied.