Abstract:Skin lesion segmentation is a critical challenge in computer vision, and it is essential to separate pathological features from healthy skin for diagnostics accurately. Traditional Convolutional Neural Networks (CNNs) are limited by narrow receptive fields, and Transformers face significant computational burdens. This paper presents a novel skin lesion segmentation framework, the Atrous Shifted Parallel Vision Mamba UNet (ASP-VMUNet), which integrates the efficient and scalable Mamba architecture to overcome limitations in traditional CNNs and computationally demanding Transformers. The framework introduces an atrous scan technique that minimizes background interference and expands the receptive field, enhancing Mamba's scanning capabilities. Additionally, the inclusion of a Parallel Vision Mamba (PVM) layer and a shift round operation optimizes feature segmentation and fosters rich inter-segment information exchange. A supplementary CNN branch with a Selective-Kernel (SK) Block further refines the segmentation by blending local and global contextual information. Tested on four benchmark datasets (ISIC16/17/18 and PH2), ASP-VMUNet demonstrates superior performance in skin lesion segmentation, validated by comprehensive ablation studies. This approach not only advances medical image segmentation but also highlights the benefits of hybrid architectures in medical imaging technology. Our code is available at https://github.com/BaoBao0926/ASP-VMUNet/tree/main.