Large Language Models for Cuffless Blood Pressure Measurement From Wearable Biosignals

Large language models (LLMs) have captured significant interest from both academia and industry due to their impressive performance across various textual tasks. However, the potential of LLMs to analyze physiological time-series data remains an emerging research field. Particularly, there is a notable gap in the utilization of LLMs for analyzing wearable biosignals to achieve cuffless blood pressure (BP) measurement, which is critical for the management of cardiovascular diseases. This paper presents the first work to explore the capacity of LLMs to perform cuffless BP estimation based on wearable biosignals. We extracted physiological features from electrocardiogram (ECG) and photoplethysmogram (PPG) signals and designed context-enhanced prompts by combining these features with BP domain knowledge and user information. Subsequently, we adapted LLMs to BP estimation tasks through fine-tuning. To evaluate the proposed approach, we conducted assessments of ten advanced LLMs using a comprehensive public dataset of wearable biosignals from 1,272 participants. The experimental results demonstrate that the optimally fine-tuned LLM significantly surpasses conventional task-specific baselines, achieving an estimation error of 0.00 $\pm$ 9.25 mmHg for systolic BP and 1.29 $\pm$ 6.37 mmHg for diastolic BP. Notably, the ablation studies highlight the benefits of our context enhancement strategy, leading to an 8.9% reduction in mean absolute error for systolic BP estimation. This paper pioneers the exploration of LLMs for cuffless BP measurement, providing a potential solution to enhance the accuracy of cuffless BP measurement.

Pi-fusion: Physics-informed diffusion model for learning fluid dynamics

Physics-informed deep learning has been developed as a novel paradigm for learning physical dynamics recently. While general physics-informed deep learning methods have shown early promise in learning fluid dynamics, they are difficult to generalize in arbitrary time instants in real-world scenario, where the fluid motion can be considered as a time-variant trajectory involved large-scale particles. Inspired by the advantage of diffusion model in learning the distribution of data, we first propose Pi-fusion, a physics-informed diffusion model for predicting the temporal evolution of velocity and pressure field in fluid dynamics. Physics-informed guidance sampling is proposed in the inference procedure of Pi-fusion to improve the accuracy and interpretability of learning fluid dynamics. Furthermore, we introduce a training strategy based on reciprocal learning to learn the quasiperiodical pattern of fluid motion and thus improve the generalizability of the model. The proposed approach are then evaluated on both synthetic and real-world dataset, by comparing it with state-of-the-art physics-informed deep learning methods. Experimental results show that the proposed approach significantly outperforms existing methods for predicting temporal evolution of velocity and pressure field, confirming its strong generalization by drawing probabilistic inference of forward process and physics-informed guidance sampling. The proposed Pi-fusion can also be generalized in learning other physical dynamics governed by partial differential equations.