Sustained Vowels for Pre- vs Post-Treatment COPD Classification

Chronic obstructive pulmonary disease (COPD) is a serious inflammatory lung disease affecting millions of people around the world. Due to an obstructed airflow from the lungs, it also becomes manifest in patients' vocal behaviour. Of particular importance is the detection of an exacerbation episode, which marks an acute phase and often requires hospitalisation and treatment. Previous work has shown that it is possible to distinguish between a pre- and a post-treatment state using automatic analysis of read speech. In this contribution, we examine whether sustained vowels can provide a complementary lens for telling apart these two states. Using a cohort of 50 patients, we show that the inclusion of sustained vowels can improve performance to up to 79\% unweighted average recall, from a 71\% baseline using read speech. We further identify and interpret the most important acoustic features that characterise the manifestation of COPD in sustained vowels.

Distinguishing between pre- and post-treatment in the speech of patients with chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) causes lung inflammation and airflow blockage leading to a variety of respiratory symptoms; it is also a leading cause of death and affects millions of individuals around the world. Patients often require treatment and hospitalisation, while no cure is currently available. As COPD predominantly affects the respiratory system, speech and non-linguistic vocalisations present a major avenue for measuring the effect of treatment. In this work, we present results on a new COPD dataset of 20 patients, showing that, by employing personalisation through speaker-level feature normalisation, we can distinguish between pre- and post-treatment speech with an unweighted average recall (UAR) of up to 82\,\% in (nested) leave-one-speaker-out cross-validation. We further identify the most important features and link them to pathological voice properties, thus enabling an auditory interpretation of treatment effects. Monitoring tools based on such approaches may help objectivise the clinical status of COPD patients and facilitate personalised treatment plans.