Optimizing Large Language Models for Detecting Symptoms of Comorbid Depression or Anxiety in Chronic Diseases: Insights from Patient Messages

Patients with diabetes are at increased risk of comorbid depression or anxiety, complicating their management. This study evaluated the performance of large language models (LLMs) in detecting these symptoms from secure patient messages. We applied multiple approaches, including engineered prompts, systemic persona, temperature adjustments, and zero-shot and few-shot learning, to identify the best-performing model and enhance performance. Three out of five LLMs demonstrated excellent performance (over 90% of F-1 and accuracy), with Llama 3.1 405B achieving 93% in both F-1 and accuracy using a zero-shot approach. While LLMs showed promise in binary classification and handling complex metrics like Patient Health Questionnaire-4, inconsistencies in challenging cases warrant further real-life assessment. The findings highlight the potential of LLMs to assist in timely screening and referrals, providing valuable empirical knowledge for real-world triage systems that could improve mental health care for patients with chronic diseases.

Can Artificial Intelligence Generate Quality Research Topics Reflecting Patient Concerns?

Patient-centered research is increasingly important in narrowing the gap between research and patient care, yet incorporating patient perspectives into health research has been inconsistent. We propose an automated framework leveraging innovative natural language processing (NLP) and artificial intelligence (AI) with patient portal messages to generate research ideas that prioritize important patient issues. We further quantified the quality of AI-generated research topics. To define patient clinical concerns, we analyzed 614,464 patient messages from 25,549 individuals with breast or skin cancer obtained from a large academic hospital (2013 to 2024), constructing a 2-staged unsupervised NLP topic model. Then, we generated research topics to resolve the defined issues using a widely used AI (ChatGPT-4o, OpenAI Inc, April 2024 version) with prompt-engineering strategies. We guided AI to perform multi-level tasks: 1) knowledge interpretation and summarization (e.g., interpreting and summarizing the NLP-defined topics), 2) knowledge generation (e.g., generating research ideas corresponding to patients issues), 3) self-reflection and correction (e.g., ensuring and revising the research ideas after searching for scientific articles), and 4) self-reassurance (e.g., confirming and finalizing the research ideas). Six highly experienced breast oncologists and dermatologists assessed the significance and novelty of AI-generated research topics using a 5-point Likert scale (1-exceptional, 5-poor). One-third of the AI-suggested research topics were highly significant and novel when both scores were lower than the average. Two-thirds of the AI-suggested topics were novel in both cancers. Our findings demonstrate that AI-generated research topics reflecting patient perspectives via a large volume of patient messages can meaningfully guide future directions in patient-centered health research.

Emerging Property of Masked Token for Effective Pre-training

Driven by the success of Masked Language Modeling (MLM), the realm of self-supervised learning for computer vision has been invigorated by the central role of Masked Image Modeling (MIM) in driving recent breakthroughs. Notwithstanding the achievements of MIM across various downstream tasks, its overall efficiency is occasionally hampered by the lengthy duration of the pre-training phase. This paper presents a perspective that the optimization of masked tokens as a means of addressing the prevailing issue. Initially, we delve into an exploration of the inherent properties that a masked token ought to possess. Within the properties, we principally dedicated to articulating and emphasizing the `data singularity' attribute inherent in masked tokens. Through a comprehensive analysis of the heterogeneity between masked tokens and visible tokens within pre-trained models, we propose a novel approach termed masked token optimization (MTO), specifically designed to improve model efficiency through weight recalibration and the enhancement of the key property of masked tokens. The proposed method serves as an adaptable solution that seamlessly integrates into any MIM approach that leverages masked tokens. As a result, MTO achieves a considerable improvement in pre-training efficiency, resulting in an approximately 50% reduction in pre-training epochs required to attain converged performance of the recent approaches.