Automatic Screening for Children with Speech Disorder using Automatic Speech Recognition: Opportunities and Challenges

Speech is a fundamental aspect of human life, crucial not only for communication but also for cognitive, social, and academic development. Children with speech disorders (SD) face significant challenges that, if unaddressed, can result in lasting negative impacts. Traditionally, speech and language assessments (SLA) have been conducted by skilled speech-language pathologists (SLPs), but there is a growing need for efficient and scalable SLA methods powered by artificial intelligence. This position paper presents a survey of existing techniques suitable for automating SLA pipelines, with an emphasis on adapting automatic speech recognition (ASR) models for children's speech, an overview of current SLAs and their automated counterparts to demonstrate the feasibility of AI-enhanced SLA pipelines, and a discussion of practical considerations, including accessibility and privacy concerns, associated with the deployment of AI-powered SLAs.

Conditional Enzyme Generation Using Protein Language Models with Adapters

The conditional generation of proteins with desired functions and/or properties is a key goal for generative models. Existing methods based on prompting of language models can generate proteins conditioned on a target functionality, such as a desired enzyme family. However, these methods are limited to simple, tokenized conditioning and have not been shown to generalize to unseen functions. In this study, we propose ProCALM (Protein Conditionally Adapted Language Model), an approach for the conditional generation of proteins using adapters to protein language models. Our specific implementation of ProCALM involves finetuning ProGen2 to incorporate conditioning representations of enzyme function and taxonomy. ProCALM matches existing methods at conditionally generating sequences from target enzyme families. Impressively, it can also generate within the joint distribution of enzymatic function and taxonomy, and it can generalize to rare and unseen enzyme families and taxonomies. Overall, ProCALM is a flexible and computationally efficient approach, and we expect that it can be extended to a wide range of generative language models.