Optimizing Hard-to-Place Kidney Allocation: A Machine Learning Approach to Center Ranking

Kidney transplantation is the preferred treatment for end-stage renal disease, yet the scarcity of donors and inefficiencies in allocation systems create major bottlenecks, resulting in prolonged wait times and alarming mortality rates. Despite their severe scarcity, timely and effective interventions to prevent non-utilization of life-saving organs remain inadequate. Expedited out-of-sequence placement of hard-to-place kidneys to centers with the highest likelihood of utilizing them has been recommended in the literature as an effective strategy to improve placement success. Nevertheless, current attempts towards this practice is non-standardized and heavily rely on the subjective judgment of the decision-makers. This paper proposes a novel data-driven, machine learning-based ranking system for allocating hard-to-place kidneys to centers with a higher likelihood of accepting and successfully transplanting them. Using the national deceased donor kidney offer and transplant datasets, we construct a unique dataset with donor-, center-, and patient-specific features. We propose a data-driven out-of-sequence placement policy that utilizes machine learning models to predict the acceptance probability of a given kidney by a set of transplant centers, ranking them accordingly based on their likelihood of acceptance. Our experiments demonstrate that the proposed policy can reduce the average number of centers considered before placement by fourfold for all kidneys and tenfold for hard-to-place kidneys. This significant reduction indicates that our method can improve the utilization of hard-to-place kidneys and accelerate their acceptance, ultimately reducing patient mortality and the risk of graft failure. Further, we utilize machine learning interpretability tools to provide insights into factors influencing the kidney allocation decisions.

A Concurrent CNN-RNN Approach for Multi-Step Wind Power Forecasting

Wind power forecasting helps with the planning for the power systems by contributing to having a higher level of certainty in decision-making. Due to the randomness inherent to meteorological events (e.g., wind speeds), making highly accurate long-term predictions for wind power can be extremely difficult. One approach to remedy this challenge is to utilize weather information from multiple points across a geographical grid to obtain a holistic view of the wind patterns, along with temporal information from the previous power outputs of the wind farms. Our proposed CNN-RNN architecture combines convolutional neural networks (CNNs) and recurrent neural networks (RNNs) to extract spatial and temporal information from multi-dimensional input data to make day-ahead predictions. In this regard, our method incorporates an ultra-wide learning view, combining data from multiple numerical weather prediction models, wind farms, and geographical locations. Additionally, we experiment with global forecasting approaches to understand the impact of training the same model over the datasets obtained from multiple different wind farms, and we employ a method where spatial information extracted from convolutional layers is passed to a tree ensemble (e.g., Light Gradient Boosting Machine (LGBM)) instead of fully connected layers. The results show that our proposed CNN-RNN architecture outperforms other models such as LGBM, Extra Tree regressor and linear regression when trained globally, but fails to replicate such performance when trained individually on each farm. We also observe that passing the spatial information from CNN to LGBM improves its performance, providing further evidence of CNN's spatial feature extraction capabilities.

Explainable boosted linear regression for time series forecasting

Time series forecasting involves collecting and analyzing past observations to develop a model to extrapolate such observations into the future. Forecasting of future events is important in many fields to support decision making as it contributes to reducing the future uncertainty. We propose explainable boosted linear regression (EBLR) algorithm for time series forecasting, which is an iterative method that starts with a base model, and explains the model's errors through regression trees. At each iteration, the path leading to highest error is added as a new variable to the base model. In this regard, our approach can be considered as an improvement over general time series models since it enables incorporating nonlinear features by residuals explanation. More importantly, use of the single rule that contributes to the error most allows for interpretable results. The proposed approach extends to probabilistic forecasting through generating prediction intervals based on the empirical error distribution. We conduct a detailed numerical study with EBLR and compare against various other approaches. We observe that EBLR substantially improves the base model performance through extracted features, and provide a comparable performance to other well established approaches. The interpretability of the model predictions and high predictive accuracy of EBLR makes it a promising method for time series forecasting.