Enhancing Retinal Disease Classification from OCTA Images via Active Learning Techniques

Eye diseases are common in older Americans and can lead to decreased vision and blindness. Recent advancements in imaging technologies allow clinicians to capture high-quality images of the retinal blood vessels via Optical Coherence Tomography Angiography (OCTA), which contain vital information for diagnosing these diseases and expediting preventative measures. OCTA provides detailed vascular imaging as compared to the solely structural information obtained by common OCT imaging. Although there have been considerable studies on OCT imaging, there have been limited to no studies exploring the role of artificial intelligence (AI) and machine learning (ML) approaches for predictive modeling with OCTA images. In this paper, we explore the use of deep learning to identify eye disease in OCTA images. However, due to the lack of labeled data, the straightforward application of deep learning doesn't necessarily yield good generalization. To this end, we utilize active learning to select the most valuable subset of data to train our model. We demonstrate that active learning subset selection greatly outperforms other strategies, such as inverse frequency class weighting, random undersampling, and oversampling, by up to 49% in F1 evaluation.

GAN-based Super-Resolution and Segmentation of Retinal Layers in Optical coherence tomography Scans

In this paper, we design a Generative Adversarial Network (GAN)-based solution for super-resolution and segmentation of optical coherence tomography (OCT) scans of the retinal layers. OCT has been identified as a non-invasive and inexpensive modality of imaging to discover potential biomarkers for the diagnosis and progress determination of neurodegenerative diseases, such as Alzheimer's Disease (AD). Current hypotheses presume the thickness of the retinal layers, which are analyzable within OCT scans, can be effective biomarkers. As a logical first step, this work concentrates on the challenging task of retinal layer segmentation and also super-resolution for higher clarity and accuracy. We propose a GAN-based segmentation model and evaluate incorporating popular networks, namely, U-Net and ResNet, in the GAN architecture with additional blocks of transposed convolution and sub-pixel convolution for the task of upscaling OCT images from low to high resolution by a factor of four. We also incorporate the Dice loss as an additional reconstruction loss term to improve the performance of this joint optimization task. Our best model configuration empirically achieved the Dice coefficient of 0.867 and mIOU of 0.765.

Superresolution and Segmentation of OCT scans using Multi-Stage adversarial Guided Attention Training

Optical coherence tomography (OCT) is one of the non-invasive and easy-to-acquire biomarkers (the thickness of the retinal layers, which is detectable within OCT scans) being investigated to diagnose Alzheimer's disease (AD). This work aims to segment the OCT images automatically; however, it is a challenging task due to various issues such as the speckle noise, small target region, and unfavorable imaging conditions. In our previous work, we have proposed the multi-stage & multi-discriminatory generative adversarial network (MultiSDGAN) to translate OCT scans in high-resolution segmentation labels. In this investigation, we aim to evaluate and compare various combinations of channel and spatial attention to the MultiSDGAN architecture to extract more powerful feature maps by capturing rich contextual relationships to improve segmentation performance. Moreover, we developed and evaluated a guided mutli-stage attention framework where we incorporated a guided attention mechanism by forcing an L-1 loss between a specifically designed binary mask and the generated attention maps. Our ablation study results on the WVU-OCT data-set in five-fold cross-validation (5-CV) suggest that the proposed MultiSDGAN with a serial attention module provides the most competitive performance, and guiding the spatial attention feature maps by binary masks further improves the performance in our proposed network. Comparing the baseline model with adding the guided-attention, our results demonstrated relative improvements of 21.44% and 19.45% on the Dice coefficient and SSIM, respectively.

Efficient OCT Image Segmentation Using Neural Architecture Search

In this work, we propose a Neural Architecture Search (NAS) for retinal layer segmentation in Optical Coherence Tomography (OCT) scans. We incorporate the Unet architecture in the NAS framework as its backbone for the segmentation of the retinal layers in our collected and pre-processed OCT image dataset. At the pre-processing stage, we conduct super resolution and image processing techniques on the raw OCT scans to improve the quality of the raw images. For our search strategy, different primitive operations are suggested to find the down- & up-sampling cell blocks, and the binary gate method is applied to make the search strategy practical for the task in hand. We empirically evaluated our method on our in-house OCT dataset. The experimental results demonstrate that the self-adapting NAS-Unet architecture substantially outperformed the competitive human-designed architecture by achieving 95.4% in mean Intersection over Union metric and 78.7% in Dice similarity coefficient.