Cross-modality image synthesis from TOF-MRA to CTA using diffusion-based models

Cerebrovascular disease often requires multiple imaging modalities for accurate diagnosis, treatment, and monitoring. Computed Tomography Angiography (CTA) and Time-of-Flight Magnetic Resonance Angiography (TOF-MRA) are two common non-invasive angiography techniques, each with distinct strengths in accessibility, safety, and diagnostic accuracy. While CTA is more widely used in acute stroke due to its faster acquisition times and higher diagnostic accuracy, TOF-MRA is preferred for its safety, as it avoids radiation exposure and contrast agent-related health risks. Despite the predominant role of CTA in clinical workflows, there is a scarcity of open-source CTA data, limiting the research and development of AI models for tasks such as large vessel occlusion detection and aneurysm segmentation. This study explores diffusion-based image-to-image translation models to generate synthetic CTA images from TOF-MRA input. We demonstrate the modality conversion from TOF-MRA to CTA and show that diffusion models outperform a traditional U-Net-based approach. Our work compares different state-of-the-art diffusion architectures and samplers, offering recommendations for optimal model performance in this cross-modality translation task.

Meta-Reinforcement Learning via Language Instructions

Although deep reinforcement learning has recently been very successful at learning complex behaviors, it requires a tremendous amount of data to learn a task. One of the fundamental reasons causing this limitation lies in the nature of the trial-and-error learning paradigm of reinforcement learning, where the agent communicates with the environment and progresses in the learning only relying on the reward signal. This is implicit and rather insufficient to learn a task well. On the contrary, humans are usually taught new skills via natural language instructions. Utilizing language instructions for robotic motion control to improve the adaptability is a recently emerged topic and challenging. In this paper, we present a meta-RL algorithm that addresses the challenge of learning skills with language instructions in multiple manipulation tasks. On the one hand, our algorithm utilizes the language instructions to shape its interpretation of the task, on the other hand, it still learns to solve task in a trial-and-error process. We evaluate our algorithm on the robotic manipulation benchmark (Meta-World) and it significantly outperforms state-of-the-art methods in terms of training and testing task success rates. Codes are available at \url{https://tumi6robot.wixsite.com/million}.