Detecting traffic signs effectively under low-light conditions remains a significant challenge. To address this issue, we propose YOLO-LLTS, an end-to-end real-time traffic sign detection algorithm specifically designed for low-light environments. Firstly, we introduce the High-Resolution Feature Map for Small Object Detection (HRFM-TOD) module to address indistinct small-object features in low-light scenarios. By leveraging high-resolution feature maps, HRFM-TOD effectively mitigates the feature dilution problem encountered in conventional PANet frameworks, thereby enhancing both detection accuracy and inference speed. Secondly, we develop the Multi-branch Feature Interaction Attention (MFIA) module, which facilitates deep feature interaction across multiple receptive fields in both channel and spatial dimensions, significantly improving the model's information extraction capabilities. Finally, we propose the Prior-Guided Enhancement Module (PGFE) to tackle common image quality challenges in low-light environments, such as noise, low contrast, and blurriness. This module employs prior knowledge to enrich image details and enhance visibility, substantially boosting detection performance. To support this research, we construct a novel dataset, the Chinese Nighttime Traffic Sign Sample Set (CNTSSS), covering diverse nighttime scenarios, including urban, highway, and rural environments under varying weather conditions. Experimental evaluations demonstrate that YOLO-LLTS achieves state-of-the-art performance, outperforming the previous best methods by 2.7% mAP50 and 1.6% mAP50:95 on TT100K-night, 1.3% mAP50 and 1.9% mAP50:95 on CNTSSS, and achieving superior results on the CCTSDB2021 dataset. Moreover, deployment experiments on edge devices confirm the real-time applicability and effectiveness of our proposed approach.