Recently, there has been a vast interest in self-supervised learning (SSL) where the model is pre-trained on large scale unlabeled data and then fine-tuned on a small labeled dataset. The common wisdom is that SSL helps resource-limited tasks in which only a limited amount of labeled data is available. The benefit of SSL keeps diminishing when the labeled training data amount increases. To our best knowledge, at most a few thousand hours of labeled data was used in the study of SSL. In contrast, the industry usually uses tens of thousands of hours of labeled data to build high-accuracy speech recognition (ASR) systems for resource-rich languages. In this study, we take the challenge to investigate whether and how SSL can improve the ASR accuracy of a state-of-the-art production-scale Transformer-Transducer model, which was built with 65 thousand hours of anonymized labeled EN-US data.