Mutual information (MI)-based guidelines have recently proven to be effective for designing task-oriented communication systems, where the ultimate goal is to extract and transmit task-relevant information for downstream task. This paper provides a comprehensive overview of MI-empowered task-oriented communication, highlighting how MI-based methods can serve as a unifying design framework in various task-oriented communication scenarios. We begin with the roadmap of MI for designing task-oriented communication systems, and then introduce the roles and applications of MI to guide feature encoding, transmission optimization, and efficient training with two case studies. We further elaborate the limitations and challenges of MI-based methods. Finally, we identify several open issues in MI-based task-oriented communication to inspire future research.