Expecting intelligent machines to efficiently work in real world requires a new method to understand unstructured information in unknown environments with good accuracy, scalability and generalization, like human. Here, a memristive neural computing based perceptual signal differential processing and learning method for intelligent machines is presented, via extracting main features of environmental information and applying associated encoded stimuli to memristors, we successfully obtain human-like ability in processing unstructured environmental information, such as amplification (>720%) and adaptation (<50%) of mechanical stimuli. The method also exhibits good scalability and generalization, validated in two typical applications of intelligent machines: object grasping and autonomous driving. In the former, a robot hand experimentally realizes safe and stable grasping, through learning unknown object features (e.g., sharp corner and smooth surface) with a single memristor in 1 ms. In the latter, the decision-making information of 10 unstructured environments in autonomous driving (e.g., overtaking cars, pedestrians) are accurately (94%) extracted with a 40x25 memristor array. By mimicking the intrinsic nature of human low-level perception mechanisms in electronic memristive neural circuits, the proposed method is adaptable to diverse sensing technologies, helping intelligent machines to generate smart high-level decisions in real world.