We propose Instruct2Attack (I2A), a language-guided semantic attack that generates semantically meaningful perturbations according to free-form language instructions. We make use of state-of-the-art latent diffusion models, where we adversarially guide the reverse diffusion process to search for an adversarial latent code conditioned on the input image and text instruction. Compared to existing noise-based and semantic attacks, I2A generates more natural and diverse adversarial examples while providing better controllability and interpretability. We further automate the attack process with GPT-4 to generate diverse image-specific text instructions. We show that I2A can successfully break state-of-the-art deep neural networks even under strong adversarial defenses, and demonstrate great transferability among a variety of network architectures.